Table 2 Diagnostic performance for cryptococcal meningitis
Test | Sensitivity (95% CI; n/N) | Specificity (95% CI; n/N) | PPV (95% CI; n/N) | NPV (95% CI; n/N) |
|---|---|---|---|---|
CrAg | 100.0 (87.5–100.0; 27 / 27) | 100.0 (86.7–100.0; 25 / 25) | 100.0 (87.5–100.0; 27 / 27) | 100.0 (86.7–100.0; 25 / 25) |
Culture | 70.4 (51.5–84.1; 19 / 27) | 100.0 (88.6–100.0; 30 / 30) | 100.0 (83.2–100.0; 19 / 19) | 78.9 (63.7–88.9; 30 / 38) |
India ink staining | 76.0 (56.6–88.5; 19 / 25) | 100.0 (84.5–100.0; 21 / 21) | 100.0 (83.2–100.0; 19 / 19) | 77.8 (59.2–89.4; 21 / 27) |
Cryptococcal PCR | 77.8 (59.2–89.4; 21 / 27) | 100.0 (20.7–100.0; 1 / 1) | 100.0 (84.5–100.0; 21 / 21) | 14.3 (2.6–51.3; 1 /7) |
NTS | 85.2 (67.5–94.1; 23 / 27) | 100.0 (88.6–100.0; 30 / 30) | 100.0 (85.7–100.0; 23 / 23) | 88.2 (73.4–95.3; 30 / 34) |