Table 1 Demographic and laboratory characteristics of the patients
Characteristics | Total (n = 57) | Cryptococcal meningitis | P value | |
|---|---|---|---|---|
No (n = 30) | Yes (n = 27) | |||
Age | 33.0[29.0,46.0] | 31.0[29.0,46.8] | 39.0[31.5,45.5] | 0.263 |
Sex | ||||
 Male | 53(93.0) | 28(93.3) | 25(92.6) | 1 |
 Female | 4(7.0) | 2(6.7) | 2(7.4) |  |
HBV coinfection | 5(8.8) | 2(6.7) | 3(11.1) | 0.66 |
HCV coinfection | 1(1.8) | 1(3.3) | 0(0.0) | 1 |
TP | 18(31.6) | 11(36.7) | 7(25.9) | 0.558 |
CD4 + T cells count (/uL) | 25.0[14.0,63.0] | 55.0[19.2,139.8] | 17.0[11.0,31.5] | 0.001 |
HIV RNA(lg copies/mL) | 4.9[4.2,5.3] | 4.8[1.9,5.0] | 5.0[4.7,5.4] | 0.116 |
 < 50 copies /mL | 4(7.4) | 3(10.3) | 1(4.0) | 0.615 |
 Missing data | 3(5.3) | 1(3.3) | 2(7.4) | 0.599 |
ART status | ||||
 Not on ART | 38(66.7) | 16(53.3) | 22(81.5) | 0.03 |
 ART ≤ 30 days | 6(10.5) | 3(10.0) | 3(11.1) |  |
 ART > 30 days | 13(22.8) | 11(36.7) | 2(7.4) |  |
Neurological symptoms | 44(77.2) | 19(63.3) | 25(92.6) | 0.011 |
CSF analysis | ||||
 CSF WBC (/uL) | 6.0[1.0,22.0] | 5.5[1.2,21.5] | 7.0[2.0,24.5] | 0.399 |
 CSF protein (mg/L) | 486.0[312.2,689.0] | 448.6[332.8,675.5] | 503.0[272.6,808.5] | 0.867 |
 CSF LDH (U/L) | 29.0[20.0,49.0] | 22.5[19.2,34.0] | 34.0[24.5,70.5] | 0.018 |
 CSF glucose (mmol/L) | 2.6[2.2,3.1] | 2.8[2.5,3.5] | 2.3[1.5,3.0] | 0.012 |
 CSF Cl (mmol/L) | 122.0[117.0,126.0] | 122.5[119.0,125.8] | 122.0[117.0,125.5] | 0.625 |
 CSF ADA (U/L) | 2.0[1.0,4.0] | 1.3[0.2,3.0] | 3.0[1.5,5.2] | 0.025 |
Other CNS infections1 | ||||
 CNS tuberculosis | 13(22.8) | 13(43.3) | 0(0.0) |  |
 Toxoplasma encephalitis | 5(8.8) | 5(16.7) | 0(0.0) |  |
 CMV encephalitis | 2(3.5) | 0(0.0) | 2(7.4) |  |
 VZV encephalitis | 1(1.8) | 1(3.3) | 0(0.0) |  |
 Neurosyphilis | 1(1.8) | 1(3.3) | 0(0) |  |
No CNS infection2 | 11(19.3) | 11(36.7) | 0(0.0) | Â |