Bigger problems from smaller colonies: emergence of antibiotic-tolerant small colony variants of Mycobacterium avium complex in MAC-pulmonary disease patients

Park, Hyun-Eui; Kim, Kyu-Min; Trinh, Minh Phuong; Yoo, Jung-Wan; Shin, Sung Jae; Shin, Min-Kyoung

doi:10.1186/s12941-024-00683-6

Annals of Clinical Microbiology and Antimicrobials

Table 3 MIC value distribution of wild-type, small colony variants, and revertant strains

From: Bigger problems from smaller colonies: emergence of antibiotic-tolerant small colony variants of Mycobacterium avium complex in MAC-pulmonary disease patients

Strains		Species	AMK	STR	RFP	RFB	ETB	CLR	FDX	MXF	CFZ	MCZ	BDQ	PTM	LZD	TZD	SQ109	TGC	INZ	EPB
#5151	WT	MI	0.5	1	≤ 0.0313	≤ 0.0078	2	≤ 0.0625	≤ 0.0625	0.125	≤ 0.0313	> 256	≤ 0.0078	8	0.5	16	8	≤ 0.0625	32	8
	SCV	MI	32	64	8	2	8	4	8	8	1	> 256	≤ 0.0078	8	64	> 256	8	> 64	128	32
	RVT	MI	1	0.5	≤ 0.0313	≤ 0.0078	4	≤ 0.0625	≤ 0.0625	≤ 0.0625	0.5	> 256	0.0078	8	0.5	8	16	1	16	0.25
#28	WT	MI	0.25	0.5	≤ 0.0313	≤ 0.0078	4	≤ 0.0625	≤ 0.0625	≤ 0.0625	0.25	> 256	≤ 0.0078	64	1	16	8	≤ 0.0625	32	0.25
	SCV	MI	32	32	8	0.5	4	8	8	4	1	> 256	0.0156	16	64	> 256	8	> 64	128	32
	RVT	MI	1	1	≤ 0.0313	0.0156	8	≤ 0.0625	0.25	0.125	1	> 256	0.0078	> 128	0.25	32	16	8	16	0.5
#410	WT	MI	2	2	0.125	≤ 0.0078	8	0.125	2	0.5	0.5	> 256	≤ 0.0078	16	2	32	16	1	64	1
	SCV	MI	32	32	8	0.5	8	4	8	4	1	> 256	≤ 0.0078	8	32	> 256	8	> 64	128	64
	RVT	MI	0.5	0.5	≤ 0.0313	≤ 0.0078	2	≤ 0.0625	≤ 0.0625	0.125	0.5	> 256	0.0078	16	0.5	8	16	4	4	0.25
#273	WT	MAA	≤ 0.125	≤ 0.125	≤ 0.0313	≤ 0.0078	1	≤ 0.0625	≤ 0.0625	≤ 0.0625	0.0625	> 256	≤ 0.0078	16	0.5	8	8	0.5	4	0.25
	SCV	MAA	8	16	1	≤ 0.0078	8	2	16	2	1	> 256	≤ 0.0078	2	16	256	8	> 64	> 256	4
	RVT	MAA	2	4	0.25	≤ 0.0078	8	0.25	4	0.25	2	> 256	0.0156	8	4	128	32	64	32	0.5
#476	WT	MAA	8	8	2	≤ 0.0078	16	4	8	4	2	> 256	≤ 0.0078	32	32	64	8	> 64	4	0.25
	SCV	MAA	16	16	4	≤ 0.0078	16	8	16	16	4	> 256	≤ 0.0078	1	64	> 256	16	> 64	> 256	8
	RVT	MAA	1	1	≤ 0.0313	≤ 0.0078	4	≤ 0.0625	0.125	0.125	2	> 256	0.0156	4	1	8	32	8	16	0.25
#3111	WT	MAA	≤ 0.125	0.25	≤ 0.0313	≤ 0.0078	1	≤ 0.0625	≤ 0.0625	≤ 0.0625	≤ 0.0313	> 256	≤ 0.0078	8	0.25	0.5	0.5	0.25	8	0.25
	SCV	MAA	32	32	2	≤ 0.0078	16	8	16	16	1	> 256	≤ 0.0078	8	32	> 256	8	> 64	> 256	32
	RVT	MAA	4	4	0.5	≤ 0.0078	8	2	2	1	0.25	> 256	0.0156	4	1	2	32	4	8	0.25
#229	WT	MAH	≤ 0.125	≤ 0.125	≤ 0.0313	≤ 0.0078	4	≤ 0.0625	≤ 0.0625	≤ 0.0625	≤ 0.0313	16	≤ 0.0078	16	0.5	0.5	4	≤ 0.0625	32	1
	SCV	MAH	8	8	16	0.5	16	8	16	4	4	16	0.0156	0.5	32	> 256	8	> 64	32	32
	RVT	MAH	16	16	16	0.25	8	8	16	1	2	> 256	0.0313	2	64	512	16	> 64	32	2
#460	WT	MAH	≤ 0.125	0.5	≤ 0.0313	≤ 0.0078	4	0.125	≤ 0.0625	≤ 0.0625	0.0625	32	≤ 0.0078	> 128	0.5	1	2	≤ 0.0625	4	≤ 0.125
	SCV	MAH	16	32	1	0.25	32	16	8	1	4	64	≤ 0.0078	4	32	> 256	8	> 64	> 256	64
	RVT	MAH	2	2	≤ 0.0313	≤ 0.0078	4	≤ 0.0625	≤ 0.0625	≤ 0.0625	1	> 256	0.0156	4	0.25	4	32	8	16	0.25
#634	WT	MAH	4	2	0.125	0.125	8	0.125	8	0.125	1	> 256	0.0313	2	2	128	16	64	8	0.25
	SCV	MAH	8	8	8	0.25	16	8	8	2	0.5	32	0.0156	1	32	> 256	8	> 64	64	32
	RVT	MAH	1	0.5	≤ 0.03125	≤ 0.0078	8	0.125	≤ 0.0625	≤ 0.0625	0.25	> 256	0.0156	4	1	32	16	16	16	0.25

The MIC values are presented up to four decimal places. Abbreviations: WT, Wild-type; SCV, Small colony-variants; RVT, Revertant; MI, Mycobacterium intracellulare; MAA, Mycobacterium avium subsp. avium; MAH, Mycobacterium avium subsp. hominissuis; AMK, Amikacin; STR, Streptomycin; RFP, Rifampicin; RFB, Rifabutin; ETB, Ethambutol; CLR, Clarithromycin; FDX, Fidaxomicin; MXF, Moxifloxacin; CFZ, Clofazimine; MCZ, Macozinone; BDQ, Bedaquiline; PTM, Prothionamide; LZD, Linezoild; TZD, Tedizolid; TGC, Tigecycline; INZ, Isoniazid; EPB, Epetraborole

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ISSN: 1476-0711

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