Clinical characteristics and drug resistance of Nocardia in Henan, China, 2017–2023

Table 5 Nocardia species identification and antibiotic risistance

Characteristics	Bronchiectasis	Non bronchiectasis	P value*
Characteristics	(n = 39)^a	(n = 29)^a	P value*
Nocardia species identifification
N.cyriacigeorgica	9 (23.1%)	3 (10.3%)	0.173
N.abscessus	8 (20.5%)	0 (0%)	0.017
N.farcinica	6 (15.4%)	12 (41.4%)	0.016
N.amamiensis	6 (15.4%)	2 (6.9%)	0.451
N.otitidiscaviarum	4 (10.3%)	1 (3.4%)	0.384
N.beijingensis	2 (5.1%)	3 (10.3%)	0.644
N.asiatica	1 (2.6%)	2 (6.9%)	0.571
N.puris	1 (2.6%)	0 (0%)	1.000
N. wallacei	1 (2.6%)	2 (6.9%)	0.571
N.pseudobrasiliensis	1 (2.6%)	0 (0%)	1.000
N.flavorosea	0 (0%)	1 (3.4%)	0.426
N.rhamnosiphila	0 (0%)	1 (3.4%)	0.426
N.africana	0 (0%)	2 (6.9%)	0.178
Antibiotic resistance profifiles
AUG	14 (35.9%)	10 (34.5%)	0.904
Ceftriaxone	9 (23.1%)	15 (51.7%)	0.014
Imipenem	14 (35.9%)	12(41.4%)	0.645
Tobramycin	3 (7.7%)	13 (44.8%)	0.000
Ciprofloxacin	25 (64.1%)	12 (41.4%)	0.063
Moxifloxacin	11 (28.2%)	10 (34.5%)	0.799
Amikacin	0 (0%)	1 (3.4%)	0.426
Linezolid	0 (0%)	0 (0%)	> 1.000
TMP-SMX	0 (0%)	0 (0%)	> 1.000
Clarithromycin	16 (41%)	15 (51.7%)	0.381
Doxycycline	1(2.6%)	0 (0%)	1.000
Minocycline	1 (2.6%)	0 (0%)	1.000

*Due to total number < 40 and some of the expected number < 5, Fisher exact test’s result was used
^aThree patients were lost to follow-up (including two pulmonary and one cutaneous), whose presence or absence of bronchiectasis was unknown due to incomplete case data

ISSN: 1476-0711