Combination antimicrobial therapy: in vitro synergistic effect of anti-staphylococcal drug oxacillin with antimicrobial peptide nisin against Staphylococcus epidermidis clinical isolates and Staphylococcus aureus biofilms

Table 3 The combined effects of oxacillin and nisin on MBEC values of oxacillin in staphylococci studied

^a Bacteria	MBEC value (µg/mL) of		Fold reduction in oxacillin MBEC in the presence of nisin
^a Bacteria	Oxacillin	Oxacillin + nisin	Fold reduction in oxacillin MBEC in the presence of nisin
SE1	8192	256	32
SE2	8192	512	16
SE3	2048	128	16
SA ATCC 43,300	4096	512	8

MBEC: Minimum biofilm eradication concentration
^a SA ATCC 43,300 is a mecA-positive, methicillin (oxacillin)-resistant Staphylococci aureus (MRSA) reference strain and SE1, SE2, and SE3 were three clinical isolates of methicillin-resistant Staphylococcus epidermidis (MRSE)

ISSN: 1476-0711