PCT, IL-6, and IL-10 facilitate early diagnosis and pathogen classifications in bloodstream infection

Table 5 Comparison of serum levels of inflammatory biomarkers and AUC between MDRO and NMDRO

Variable	CRP (mg/L)			PCT (ng/ml)			IL-6 (pg/ml)			IL-10 (pg/ml)
Variable	median (IQR)	P value	AUC	median (IQR)	P value	AUC	median (IQR)	P value	AUC	median (IQR)	P value	AUC
CRE	134.80 (77.77,210.90)	0.68	0.53	12.77 (2.45,58.80)	0.73	0.50	397.80 (275.20,4633.00)	0.09	0.60	66.09 (35.93,202.30)	0.93	0.51
CSE	126.00 (61.67,222.40)	0.68	0.53	10.61 (1.72,39.85)	0.73	0.50	397.40 (119.00,1399.00)	0.09	0.60	67.78 (21.19,188.40)	0.93	0.51
CRPA	48.66 (22.77,290.70)	0.89	0.51	18.75 (7.34,79.18)	0.55	0.60	728.40 (184.60,2274.00)	0.74	0.67	53.14 (21.36,571.6)	0.4	0.57
CSPA	45.99 (19.34,294.40)	0.89	0.51	13.34 (3.62,50.86)	0.55	0.60	469.70 (96.13,1650.00)	0.74	0.67	63.84 (13.71,213.00)	0.4	0.57
MRSA	88.00 (41.09,199.40)	0.98	0.51	0.86 (0.20,6.53)	0.08	0.61	127.40 (60.37,209.50)	0.94	0.56	5.55 (1.30,16.92)	0.68	0.57
MSSA	94.00 (52.20,192.70)	0.98	0.51	0.46 (0.14,1.65)	0.08	0.61	180.70 (94.79,236.80)	0.94	0.56	5.88 (2.15,18.74)	0.68	0.57
VRE	133.90 (75.11,261.10)	0.23	0.73	2.49 (0.55,27.96)	0.03	0.75	181.40 (101.50,243.60)	0.6	0.57	22.01 (8.64,59.76)	0.06	0.75
VSE	69.45 (29.49,150.20)	0.23	0.73	0.48 (0.12,2.28)	0.03	0.75	164.00 (103.40,203.60)	0.6	0.57	65.05 (5.21,19.53)	0.06	0.75

MDRO, multidrug resistant organism; NMDRO, non- multidrug resistant organism; CRE, carbapenem resistant enterobacteriacea; CSE, carbapenem susceptible enterobacteriacea; CRPA, carbapenem resistant pseudomonas aeruginosa; CSPA, carbapenem susceptible pseudomonas aeruginosa; MRSA, methicillin resistant staphylococcus aureus; MSSA, methicillin susceptible staphylococcus aureus; VRE, vancomycin resistant enterococcus; VSE, vancomycin susceptible enterococcus

ISSN: 1476-0711