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Table 1 MICs of antimicrobial agents for isolates from multiple body site, mCIM/eCIM interpretations and PCR results

From: Phenotypic and genotypic discrepancies for carbapenemase-producing Citrobacter freundii in multiple isolates from a single patient

Antimicrobials

Samples

BC-1

BC-2

BC-3

K-1

K-2

Amikacin (µg/ml)

 ≤ 16 (S)

 ≤ 16 (S)

 ≤ 16 (S)

 ≤ 16 (S)

 ≤ 16 (S)

Aztreonam (µg/ml)

 ≤ 4 (S)

 ≤ 4 (S)

 > 16 (R)

 > 16 (R)

 > 16 (R)

Cefepime (µg/ml)

 ≤ 2 (S)

 ≤ 2 (S)

8 (SDD)

 > 16 (R)

 > 16 (R)

Cefotaxime (µg/ml)

8 (R)

 ≤ 2 (S)

 > 32 (R)

 > 32 (R)

 > 32 (R)

Ceftazidime (µg/ml)

4 (S)

4 (S)

16 (R)

 > 16 (R)

16 (R)

Ceftazidime/Avibactam (µg/ml)

 ≤ 4 (S)

 ≤ 4 (S)

 ≤ 4 (S)

 ≤ 4 (S)

 ≤ 4 (S)

Ceftolozane/Tazobactam (µg/ml)

 ≤ 2 (S)

 ≤ 2 (S)

8 (R)

8 (R)

8 (R)

Ceftriaxone (µg/ml)

8 (R)

2 (I)

8 (R)

 > 32 (R)

 > 32 (R)

Ciprofloxacin (µg/ml)

1 (R)

1 (R)

 > 2 (R)

 > 2 (R)

 > 2 (R)

Ertapenem (µg/ml)

 ≤ 0.5 (S)

 ≤ 0.5 (S)

1 (I)

1 (I)

 ≤ 0.5 (S)

Gentamicin (µg/ml)

 ≤ 2 (S)

 ≤ 2 (S)

8 (I)

 > 8 (R)

4 (S)

Imipenem (µg/ml)

2 (I)

2 (I)

2 (I)

2 (I)

2 (I)

Levofloxacin (µg/ml)

 ≤ 0.5 (S)

 ≤ 0.5 (S)

 > 4 (R)

 > 4 (R)

 > 4 (R)

Meropenem (µg/ml)

 ≤ 1 (S)

 ≤ 1 (S)

 ≤ 1 (S)

 ≤ 1 (S)

 ≤ 1 (S)

Meropenem/Vaborbactam (µg/ml)

 ≤ 2 (S)

 ≤ 2 (S)

 ≤ 2 (S)

 ≤ 2 (S)

 ≤ 2 (S)

Moxifloxacin (µg/ml)

 ≤ 2 (S)

 ≤ 2 (S)

 > 4 (R)

 > 4 (R)

 > 4 (R)

Piperacillin/Tazobactam (µg/ml)

 ≤ 8 (S)

 ≤ 8 (S)

32 (R)

64 (R)

64 (R)

Tobramycin (µg/ml)

 ≤ 2 (S)

 ≤ 2 (S)

8 (I)

 > 8 (R)

8 (I)

mCIM/eCIM interpretation

Serine carbapenemase detected

Serine carbapenemase detected

Serine carbapenemase detected

Serine carbapenemase detected

Serine carbapenemase detected

Carbapenemase gene detected a

blaKPC

blaKPC

blaKPC

blaKPC

blaKPC

  1. MICs in µg/ml and categorical interpretation (in parentheses)
  2. Interpretation of MICs from CLSI M100 S32 2022
  3. S Susceptible; I Intermediate; SDD Susceptible Dose Dependent; R Resistant
  4. aKPC target identified on the Xpert Carba-R assay (Cepheid)