Phenotypic and genotypic characterization of linezolid resistance and the effect of antibiotic combinations on methicillin-resistant Staphylococcus aureus clinical isolates

Table 2 Distribution of methicillin-resistant isolates (n = 159) based on minimum inhibitory concentrations (MICs) of linezolid, and the other antimicrobials; chloramphenicol, ciprofloxacin, erythromycin, gentamicin, tigecycline, and vancomycin, in mg/L

Antimicrobial	Minimum inhibitory concentration (mg/L)
Antimicrobial	< 2	2	4	8	16	32	64	128	256	512	1024	> 1024
CHL	0	35	25	45	12*	5*	14*	23*	0	0	0	0
CIP	31	48	13*	5*	24*	7*	9*	8*	3*	9*	2*	0
ERY	51	7	21*	43*	3*	12*	18*	4*	0	0	0	0
GEN	0	67	11	5*	2*	37*	5*	9*	11*	5*	7*	0
LZD	0	54	97	2*	1*	1*	1*	3*	0	0	0	0
TGC	142	3*	13*	1*	0	0	0	0	0	0	0	0
VAN	0	17	76	37	3*	2*	10*	8*	3*	3*	0	0

Results were interpreted according to the clinical breakpoints of CLSI, M07-A10 protocol, and to the breakpoint tables version 10.0, 2020 of the European Committee on Antimicrobial Susceptibility Testing (EUCAST) for tigecycline, the resistant isolates are denoted by asterisk

ISSN: 1476-0711