Table 1 Comparison of in-vitro activities of seven antifungal agents tested against dermatophytes species isolated from patients by CLSI method
Dermatophyte species No. (%) | Antifungal agents | Range (μg/mL) | MIC/MEC50a (μg/mL) | MIC/MEC90 (μg/mL) | GM MICa (μg/mL) |
|---|---|---|---|---|---|
Trichophyton mentagrophytes76 (38.4%) | Terbinafine Griseofulvin Caspofungin Fluconazole Itraconazole Luliconazole Isavuconazole | 0.016–8 0.25–8 0.016–8 0.5–32 0.016–8 0.008–2 0.008–2 | 0.25 2 0.016 32 2 0.016 0.016 | 2 4 4 32 8 0.125 0.125 | 0.209 2.356 0.077 24.788 1.610 0.022 0.177 |
Trichophyton interdigitale 57 (28.8%) | Terbinafine Griseofulvin Caspofungin Fluconazole Itraconazole Luliconazole Isavuconazole | 0.016–8 0.016–8 0.016–4 4–32 0.016–8 0.08–0.5 0.008–2 | 0.032 1 0.016 32 1 0.008 0.032 | 1 4 4 32 4 0.25 0.5 | 0.080 0.915 0.060 24.438 1.0142 0.019 0.049 |
Trichophyton rubrum 34 (17.2%) | Terbinafine Griseofulvin Caspofungin Fluconazole Itraconazole Luliconazole Isavuconazole | 0.016–8 0.016–4 0.016–8 0.064–32 0.016–8 0.08–0.016 0.08–1 | 0.032 0.5 0.016 16 0.5 0.008 0.032 | 0.25 4 1 32 4 0.008 0.5 | 0.038 0.534 0.041 7.379 0.411 0.008 0.044 |
Trichophyton tonsurans 12 (6.1%) | Terbinafine Griseofulvin Caspofungin Fluconazole Itraconazole Luliconazole Isavuconazole | 0.016–8 0.016–8 0.016–4 2–32 0.016–8 0.08–0.125 0.008–1 | 0.032 1 0.016 16 2 0.008 0.008 | 0.125 4 0.125 32 4 0.125 0.125 | 0.049 0.477 0.039 18.775 0.407 0.029 0.026 |
Microsporum canis 10 (5%) | Terbinafine Griseofulvin Caspofungin Fluconazole Itraconazole Luliconazole Isavuconazole | 0.016–8 0.064–4 0.016–0.125 0.5–32 0.016–1 0.08–2 0.008–4 | 0.032 0.125 0.032 1 0.25 0.008 0.008 | 0.064 4 0.125 4 0.5 0.125 0.25 | 0.040 0.171 0.034 1.360 0.117 0.020 0.025 |
Species with less than 10 isolatesb 9 (4.5%) | Terbinafine Griseofulvin Caspofungin Fluconazole Itraconazole Luliconazole Isavuconazole | 0.016–0.064 0.032–4 0.016–8 1–32 0.032–8 0.008–0.032 0.008–0.5 | 0.016 0.5 0.032 8 1 0.008 0.032 | 0.064 2 4 32 1 0.032 0.125 | 0.238 0.279 0.115 8.832 0.556 0.112 0.047 |
Total 198 (100%) | Terbinafine Griseofulvin Caspofungin Fluconazole Itraconazole Luliconazole Isavuconazole | 0.016–8 0.016–8 0.016–8 0.064–32 0.016–8 0.08–2 0.008–8 | 0.064 2 0.016 32 1 0.008 0.064 | 1 4 4 32 8 0.25 2 | 0.091 1.010 0.061 16.524 0.861 0.018 0.074 |