Table 2 The area under the curve (AUC), cut-off values, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPP) for soluble triggering receptor expressed on myeloid cells-1 (sTREM-1), procalcitonin, lactate dehydrogenase, C-reactive protein, white blood cells count, and erythrocyte sedimentation rate in invasive aspergillosis cases
From: Role of biomarkers in the diagnosis of invasive aspergillosis in immunocompromised patients
|  |  |  | P value < 0.001 |  |  |  |
|---|---|---|---|---|---|---|
| Â | sTREM*-1 | Procalcitonin | Lactate dehydrogenase | C-reactive protein | White blood cells | Erythrocyte sedimentation rate |
AUC | 0.74 | 0.93 | 0.96 | 0.97 | 0.71 | 0.95 |
95% Confidence interval | 0.59 to 0.88 | 0.86 to 0.99 | 0.91 to 1 | 0.92 to 1 | 0.57 to 0.85 | 0.88 to 1 |
Cut-off value | > 190pg/mL | > 260pg/mL | > 193U/L | > 5 mg/L | < 5200 cell/L | > 19 mm/h |
Sensitivity | 70.6% | 71% | 85.3% | 94.1% | 64.7% | 85.3% |
Specificity | 100% | 100% | 94.1% | 100% | 100% | 100% |
PPV | 100% | 100% | 96.7% | 100% | 100% | 100% |
NPV | 63% | 63% | 76.2% | 89.5% | 58.6% | 77.3% |