Table 1 Baseline characteristics of the patients with mono-candidemia and mixed C/B-BSIs
Characteristics | Total (n = 296) | mono-candidemia (n = 218) | mixed C/B-BSIs (n = 78) | P value |
|---|---|---|---|---|
Age, median years (IQR) | 65.0 (53.0–75.0) | 67.0 (53.0–75.0) | 63.5 (51.0–75.5) | 0.45 |
Male sex [n (%)] | 188 (63.5) | 132 (60.6) | 56 (71.8) | 0.08 |
APACHE II score at the onset of candidemia (mean ± S.D.) | 21.9 ± 7.4 | 21.8 ± 7.2 | 22.2 ± 7.8 | 0.71 |
SOFA score at the onset of candidemia (IQR) | 6.0 (3.0–9.0) | 5.0 (3.0–8.0) | 7.0 (4.0–10.3) |  < 0.01 |
GCS score at the onset of candidemia (IQR) | 15.0 (8.0–15.0) | 15.0 (8.0–15.0) | 13.0 (6.8–15.0) | 0.02 |
Prior ICU stay (days) (IQR) | 5.0 (0.0–19.0) | 2.0 (0.0–17.0) | 11.0 (1.0–22.3) |  < 0.01 |
Prior hospital stay (days) (IQR) | 15.5 (6.0–31.8) | 14.0 (5.0–30.3) | 19.0 (10.0–35.5) | 0.01 |
Underlying disease [n (%)] | Â | Â | Â | Â |
  Diabetes mellitus | 51 (17.2) | 39 (17.9) | 12 (15.4) | 0.61 |
  Chronic cardiac dysfunction | 51 (17.2) | 32 (14.7) | 19 (24.2) | 0.05 |
  Chronic obstructive pulmonary disease | 18 (6.1) | 13 (6.0) | 5 (6.4) | 0.89 |
  Chronic renal insufficiency | 27 (9.1) | 22 (10.1) | 5 (6.4) | 0.33 |
  Chronic hepatic insufficiency | 29 (9.8) | 24 (11.0) | 5 (6.4) | 0.24 |
  Solid tumour | 77 (26.0) | 61 (28.0) | 16 (20.5) | 0.20 |
  Haematological malignancy | 11 (3.7) | 9 (4.1) | 2 (2.6) | 0.78 |
  Trauma | 51 (17.2) | 33 (15.1) | 18 (23.1) | 0.11 |
  Burn injury | 15 (5.1) | 7 (3.2) | 8 (10.3) | 0.03 |
  Transplant | 4 (1.4) | 2 (0.9) | 2 (2.6) | 0.61 |
  Cerebrovascular accident | 99 (33.4) | 74 (33.9) | 25 (32.1) | 0.76 |
Immunocompromised [n (%)] | Â | Â | Â | Â |
  Immunosuppressant therapy | 9 (3.0) | 7 (3.2) | 2 (2.6) |  > 0.99 |
  Steroid therapy | 16 (5.4) | 13 (6.0) | 3 (3.8) | 0.68 |
  Chemotherapy/radiation | 44 (14.9) | 35 (16.1) | 9 (11.5) | 0.34 |
  Neutropenia | 12 (4.1) | 9 (4.2) | 3 (3.9) | 0.91 |
Hospitalization ward [n (%)] | Â | |||
  Medical | 44 (14.9) | 36 (16.5) | 8 (10.3) | 0.18 |
  Surgical | 60 (20.3) | 49 (22.5) | 11 (14.1) | 0.11 |
  ICU | 191 (64.5) | 133 (61.0) | 58 (74.4) | 0.03 |
Life-sustaining treatments ≥ 24 h [n (%)] |  | |||
  Invasive mechanical ventilation | 179 (60.5) | 121 (55.5) | 58 (74.4) |  < 0.01 |
  Vasopressor | 113 (38.4) | 76 (35.0) | 37 (48.1) | 0.04 |
  CRRT | 74 (25) | 42 (19.3) | 32 (41.0) |  < 0.001 |
  ECMO | 5 (1.7) | 1 (0.5) | 4 (5.3) | 0.02 |
Catheterisation a[n (%)] | Â | Â | Â | Â |
  Central venous catheterb | 240 (81.1) | 172 (78.9) | 68 (87.2) | 0.11 |
  Hemodialysis catheterc | 36 (12.2) | 22 (10.1) | 14 (17.9) | 0.07 |
  PICC | 54 (18.2) | 39 (17.9) | 15 (19.2) | 0.79 |
  Peripheral arterial catheters | 93 (31.4) | 61 (28.0) | 32 (41.0) | 0.03 |
  Drainage tube |  |  |  |  |
    Abdominal drainage tube | 83 (28.0) | 64 (29.4) | 19 (24.4) | 0.40 |
    Biliary drainage tube | 10 (3.4) | 7 (3.2) | 3 (3.8) |  > 0.99 |
    Thoracic drainage tube | 47 (15.9) | 29 (13.3) | 18 (23.1) | 0.04 |
    Intracranial drainage tube | 47 (15.9) | 34 (15.6) | 13 (16.7) | 0.82 |
  Urethral catheter | 263 (88.9) | 191 (87.6) | 72 (92.3) | 0.26 |
Presence of two or more catheters | 260 (87.8) | 186 (85.3) | 74 (94.9) | 0.03 |
Presence of three or more catheters | 195 (65.9) | 135 (61.9) | 60 (76.9) | 0.02 |
Presence of two or more central venous catheters | 60 (20.3) | 38 (17.4) | 22 (28.2) | 0.04 |
Total parenteral nutrition [n (%)] | 198 (66.9) | 137 (62.8) | 61 (78.2) | 0.01 |
Blood transfusion [n (%)] | 105 (35.5) | 67 (30.7) | 38 (48.7) |  < 0.01 |
Surgery [n (%)] | 164 (55.4) | 114 (52.3) | 50 (64.1) | 0.07 |
  Abdominal | 63 (21.3) | 46 (21.1) | 17 (21.8) | 0.90 |