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Table 3 The effect of mutations on FolC protein stability

From: Determination of critical concentration for drug susceptibility testing of Mycobacterium tuberculosis against para-aminosalicylic acid with clinical isolates with thyA, folC and dfrA mutations

Amino acid change

MIC

ΔΔG (kcal/mol) a

Eris

PremPS

R49P

 > 32

2.91

1.27

S98G

32

1.39

1.13

K144T

8

3.89

−0.01

S150G

 > 32

1.67

0.73

E153A

8

−1.13

0.44

R341C

32

1.79

0.38

  1. aThe free energy (ΔΔG) was calculated for point mutations in the available protein structures by using two endpoint methods, namely, Eris and PremPS. ΔΔG < 0, stabilizing mutations; ΔΔG > 0, destabilizing mutations
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Annals of Clinical Microbiology and Antimicrobials

ISSN: 1476-0711

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