Fig. 10

Terbinafine altered S. aureus mice pathogenesis. A Increase in organ weight of pigmented bacteria inoculated mice compared to terbinafine treated and non-pigmented inoculated mice. B Bacterial load of liver, spleen and kidney of each group. C Histopathological organ section from pigmented, terbinafine treated and non-pigmented isolate stained by hematoxylin and eosin stain. (I) Liver with diffuse areas of caseous necrosis. (II) Degeneration of some renal tubules represented in cloudy swelling (III) Focal necrosis of some spleen lymphocytes in the white pulp. (IV) Normal hepatic parenchyma with normal tissue architecture and cellular details. (V) Focal cystic dilation of some renal tubules (arrowhead). (VI) Spleen with depleted white pulp lymphocytes. (VII) Hepatic blood vessels with diffuse congestion (arrows) and dilated sinusoids. (VIII) Kidney with diffused cystic dilation of some renal tubules in the renal medulla. (IX) Spleen with focal vacuolar degeneration. Each symbol represents the value for an individual mouse and horizontal bars indicate the means. Using Mann–Whitney U analysis, P value < 0.05 was considered statistically significant