Table 1 Underlying clinical conditions, antibiotic therapy, outcome, and phenotypic analyze
Isolate ID Year MLST | Underlying clinical condition | Impiric treatment | Culture guided added tratment | Outcome | Phenotypic Tests—Serina-β-lactamases (DD mm) | Phenotypic Tests—MBLs (DD mm) | Carbapenem-bac |
|---|---|---|---|---|---|---|---|
K. pneumoniae (KP1411) 10/19/2012 ST340 | Myelodysplastic syndrome Leukocytes: 100 Neutrophils: 0 Allogeneic BMT (10/11/2012) | Meropenem | Tigecycline Colistin | Death 2 days after blood positive culture | DD (mm) IMP: 0 ERT: 0 MPM: 0 DD (mm) agent’s combination: MPM + PBA: 14 mm MPM + EDTA + PBA: 17 mm | DD (mm) IMP: 0 ERT: 0 MPM: 0DD (mm) agent’s combination: MPM + EDTA: 0 (phantom zone 14) MPM + EDTA + PBA: 17 mm | Positive |
K. pneumoniae (KP1581) 12/14/2012 ST340 | Severe aplastic anemia Leukocytes: 100 Neutrophils: 0 Not related allogeneic TCTH (12/09/2012) | Meropenem | Tigecycline Colistin | Death 2 days after blood positive culture | DD (mm) IMP: 23 mm ERT: 16 mm MPM: 20 mm DD (mm) agent’s combination: MPM + PBA: 23 mm MPM + EDTA + PBA: 23 mm | DD (mm) IMP: 23 mm ERT: 16 mm MPM: 20 mm DD (mm) agent’s combination: MPM + EDTA: 21 mm MPM + EDTA + PBA: 23 mm | Positive |
K. pneumoniae (KP4301) 10/16/2014 ST340 | Non-Hodgkin lymphoma Peripheral T-cell lymphoma Leukocytes: 3,33 Neutrophils: 2,43 Autologous BMT 9/17/2014 | Cefepime | Tigecycline Colistin | Discharge from hospital 23 days after blood positive culture, for a total of 64 days hospitalization | DD (mm) IMP: 0 ERT: 0 MPM: 0 DD (mm) agent’s combination: MPM + PBA: 13 mm MPM + EDTA + PBA: 18 mm | DD (mm) IMP: 0 ERT: 0 MPM: 0 DD (mm) agent’s combination: MPM + EDTA: 10 (phantom zone 14) MPM + EDTA + PBA: 18 mm | Positive |
S. marcescens (SM1756) 6/14/2013 | Necrotizing fasciitis Amputation of the right arm (05/31/13) Complication: Ischemic cecum perforation (6/07/2013) | Ciprofloxacin Clindamycin | Tigecycline Fosfomycin | Death 11 days after blood positive culture | DD (mm) IMP: 13 mm ERT: 17 mm MPM: 23 mm DD (mm) agent’s combination: MPM + PBA: 25 mm MPM + EDTA + PBA: 26 mm | DD (mm) IMP: 13 mm ERT: 17 mm MPM: 23 mm DD (mm) agent’s combination: MPM + EDTA: 19 mm MPM + EDTA + PBA: 26 mm | Positive |
K. pneumoniae (KP4990) 10/21/16 ST258 | Kidney transplant due Chronic Kidney Disease (10/13/16) Urinary tract infection (10/20/16) Graft Nephrectomy (11/23/16) | Meropenem | Ceftazidime + Avibactam | Death 40 days after blood positive culture | DD (mm) IMP: 6 mm ERT: 0 MPM: 0 (phantom zone 7 mm) DD (mm) agent’s combination: MPM + PBA: 14 mm MPM + EDTA + PBA: 16 mm (phantom zone 20) | DD (mm) IMP: 6 mm ERT: 0 MPM: 0 (phantom zone 7 mm) DD (mm) agent’s combination: MPM + EDTA: 9 mm (phantom zone 20) MPM + EDTA + PBA: 16 mm (phantom zone 20) | Positive |