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Table 2 Confirmation methods and treatment of CNS aspergillosis in patients with leukemia or stem cell transplantations

From: Aspergillosis of central nervous system in patients with leukemia and stem cell transplantation: a systematic review of case reports

Confirmation methods

 

 Histopathological examination (HE)

39%

 HE and culture

18.70%

 Culture

5%

 Post-mortem

5%

 Aspergillus galactomannan (GM)

8.50%

 GM assay and PCR

1.70%

 PCR

1.70%

 Non-CNS samples

20.40%

Medical imaging modalities

 

 Ring enhancing lesions

57%

 Perifocal edema on MRI

56%

 Brain hemorrhages

3.30%

 Nonspecific hyper intense foci

1.70%

Treatment

 

 Amphotericin B

76%

 Voriconazole

64%

 Caspofungin

18.60%

 Itraconazole

15.20%

 Isavuconazole

8.50%

 Flucytosine

6.70%

 Micafungin

6.70%

 Fluconazole

5%

 Posaconazole

5%

 Surgery

39%