Table 1 Demographic and clinical data for patients with Candida bloodstream infection
| Â | C. albicans | C. parapsilosis | C. tropicalis | C. glabrata | C. guilliermondii | C sake | C krusei | Other Candida spp. | Total |
|---|---|---|---|---|---|---|---|---|---|
|  | (n = 141) | (n = 87) | (n = 69) | (n = 48) | (n = 20) | (n = 8) | (n = 5) | (n = 15) | (n = 393) |
Age, years | 65.2 ± 14.5 | 53.2 ± 20.3 | 50.5 ± 19.5 | 60.7 ± 17.5 | 50.5 ± 19.4 | 52 ± 20.6 | 40.8 ± 27.1 | 52.6 ± 20.0 | 57.6 ± 19.0 |
Male | 102(73.4) | 60(69.0) | 51(73.9) | 44(91.7) | 14(70) | 8(100) | 2(40) | 11(73.3) | 292(74.3) |
Origin | |||||||||
Internal medicine ward | 15(10.6) | 19(21.8) | 27(39.1) | 7(14.6) | 3(15) | 0(0) | 3(60) | 4(26.7) | 78(19.8) |
Surgical ward | 61(43.3) | 32(36.8) | 16(23.2) | 15(31.3) | 10(50) | 6(75) | 0(0) | 8(53.3) | 148(37.7) |
ICU | 65(46.1) | 36(41.4) | 26(37.7) | 26(54.1) | 7(35) | 2(25) | 2(40) | 3(20) | 167(42.5) |
Time from admission to infection, days | 30.6 ± 35.3 | 48.4 ± 56.2 | 37.7 ± 32.4 | 27.5 ± 19.1 | 35.9 ± 52.5 | 120.6 ± 242.7 | 64.2 ± 68.6 | 21.5 ± 13.6 | 37.6 ± 53.1 |
Length of hospital stay, days | 56.0 ± 54.9 | 83.2 ± 78.1 | 71.5 ± 56.1 | 67.1 ± 72.7 | 97.7 ± 142.6 | 178.5 ± 281.7 | 92.4 ± 88.5 | 52.7 ± 101.5 | 71.1 ± 82.8 |
Turnaround time, days | 4.3 ± 1.9 | 4.5 ± 1.1 | 3.8 ± 1.1 | 4.8 ± 1.3 | 4.3 ± 1.2 | 4.5 ± 1.6 | 4.4 ± 1.5 | 5.9 ± 1.8 | 4.4 ± 1.5 |
Underlying disease | |||||||||
Solid tumor | 47(33.3) | 26(29.9) | 13(18.8) | 17(35.4) | 6(30) | 2(25) | 0(0) | 7(46.7) | 118(30) |
Hematologic malignancy | 8(5.7) | 6(6.9) | 24(34.8) | 2(4.2) | 2(10) | 1(12.5) | 3(60) | 2(13.3) | 48(12.2) |
Diabetes mellitus | 33(23.4) | 21(24.1) | 8(11.6) | 9(18.8) | 1(5) | 1(12.5) | 0(0) | 4(26.7) | 77(19.6) |
Chronic cardiac disease | 55(39) | 22(25.3) | 16(23.2) | 18(37.5) | 6(30) | 3(37.5) | 2(40) | 2(13.3) | 124(31.6) |
Chronic pulmonary disease | 26(18.4) | 9(10.3) | 5(7.2) | 6(12.5) | 1(5) | 1(12.5) | 1(20) | 3(20) | 52(13.2) |
Chronic renal failure | 18(12.8) | 6(6.9) | 6(8.7) | 5(10.4) | 5(25) | 0(0) | 0(0) | 2(13.3) | 42(10.7) |
Skin barrier compromised | 5(3.5) | 9(10.3) | 5(7.2) | 1(2.1) | 3(15) | 3(37.5) | 0(0) | 0(0) | 26(6.6) |
Prior surgical intervention (< 1 month) | 97(68.8) | 48(55.2) | 36(52.2) | 30(62.5) | 15(75) | 6(75) | 2(40) | 10(66.7) | 244(62.1) |
Corticosteroid use | 11(7.8) | 13(14.9) | 12(17.4) | 9(18.8) | 4(20) | 0(0) | 3(60) | 2(13.3) | 54(13.7) |
Prior use of antifungal agents (< 6 months) | 20(14.2) | 19(21.8) | 24(34.8) | 11(22.9) | 8(40) | 1(12.5) | 4(80) | 1(6.7) | 88(22.4) |
Severity of clinical feature | |||||||||
Fever (T > 38.2 ℃) | 114(80.9) | 63(72.4) | 60(87) | 34(70.8) | 16(80) | 6(75) | 3(60) | 13(86.7) | 309(78.6) |
Parenteral nutrition | 71(50.4) | 42(48.3) | 28(40.6) | 23(47.9) | 5(25) | 3(37.5) | 2(40) | 6(40) | 180(45.8) |
Mechanical ventilation | 58(41.1) | 31(35.6) | 23(33.3) | 25(52.1) | 5(25) | 2(25) | 2(40) | 1(6.7) | 147(37.4) |
Renal replacement therapy | 17(12.1) | 10(11.5) | 9(13) | 7(14.6) | 5(25) | 0(0) | 1(20) | 0(0) | 49(12.5) |
Central venous catheter | 121(85.8) | 67(77) | 49(71) | 43(89.6) | 17(85) | 5(62.5) | 4(80) | 10(66.7) | 316(80.4) |
Severe neutropenia | 4(2.8) | 8(9.2) | 22(31.9) | 1(2.1) | 2(10) | 0(0) | 3(60) | 2(13.3) | 42(10.7) |
28-day mortality | 54(38.3) | 16(18.4) | 19(27.5) | 13(27.1) | 3(15) | 1(12.5) | 1(20) | 5(33.3) | 112(28.5) |