Patients | Sex | Age (years) | Weight (kg) | C0 (µg/mL) | C1 | C2 | C3 | C4 | C6 | C8 | C12 | AUC0–12 (µg h/mL) | Cl(L/h/kg) | Cmax | Tmax |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
First group (RBT 150 mg TPW) | |||||||||||||||
Patient1 | F | 39 | 50.5 | 1.2 | 0.4 | 1.7 | 0.64 | 1.28 | 0.7 | 2.4 | 0.2 | 7.8 | 0.25 | 1.28 | 4 |
Patient3 | M | 36 | 56.8 | 2.1 | 1.86 | 2.5 | 0.4 | 0.5 | 1 | 1 | 1.33 | 8.9 | 0.19 | 1.86 | 1 |
Patient5 | M | 43 | 45.2 | 1.43 | 2 | 2.24 | 1.81 | 2.26 | 1.42 | 1.5 | 1.7 | 12.8 | 0.17 | 2.26 | 4 |
Patient7 | M | 32 | 44 | 2.1 | 1.56 | 1.56 | 1.26 | 1.3 | 2.74 | 1.91 | 1.7 | 12.2 | 0.18 | 2.74 | 6 |
Patient9 | F | 39 | 36 | 2.96 | 2.5 | 2.87 | 3.16 | 2.74 | 2.42 | 1.93 | 2.84 | 18.5 | 0.15 | 3.16 | 3 |
Patient11 | F | 33 | 57.6 | 7.5 | 8 | 10.3 | 10.8 | 11.5 | 10.7 | 8.2 | 8.3 | 67.4 | 0.03 | 11.5 | 4 |
Patient13 | M | 34 | 55 | 1.85 | 1.91 | 1.72 | 1.65 | 1.2 | 1.64 | 1.24 | 1.1 | 10.8 | 0.17 | 1.91 | 1 |
Patient15 | M | 24 | 52 | 4.11 | 3.8 | 3.6 | 3.5 | 2.7 | 3.3 | 2.8 | 3.6 | 23.5 | 0.08 | 3.6 | 2 |
Patient17 | M | 47 | 60 | 3.1 | 3.1 | 2.6 | 2.9 | 1.7 | 1.5 | 1.2 | 0.6 | 14.8 | 0.11 | 2.9 | 3 |
Second group (RBT 300 mg TPW) | |||||||||||||||
Patient2 | F | 33 | 40 | Low | Low | 1 | 1.33 | 1.44 | 1.22 | 1.1 | 0.62 | 6.4 | 0.39 | 1.44 | 4 |
Patient4 | M | 44 | 55 | 0.41 | 0.37 | 0.4 | 0.3 | 0.38 | 0.3 | 0.28 | low | 2.2 | 0.81 | 0.4 | 2 |
Patient6 | F | 33 | 40.1 | 0.2 | Low | 0.8 | 0.8 | 0.9 | 0.8 | 0.9 | 0.6 | 4.6 | 0.54 | 0.9 | 4 |
Patient8 | M | 32 | 60.8 | 2.72 | 1.97 | 2.22 | 1.41 | 0.95 | 1.45 | 0.66 | 0.53 | 10.3 | 0.16 | 2.22 | 2 |
Patient10 | F | 32 | 40.2 | 1.84 | 2.14 | 2.43 | 2.4 | 1.67 | 1.3 | 1 | 0.7 | 12.2 | 0.20 | 2.43 | 2 |
Patient12 | F | 25 | 49.2 | 1.55 | 1.64 | 1.9 | 1.9 | 2 | 2.5 | 2 | 1.86 | 13.6 | 0.15 | 2.5 | 6 |
Patient14 | F | 44 | 52 | 2.3 | 1.5 | 1.12 | 1.2 | 1 | 0.5 | 0.13 | Low | 6.6 | 0.29 | 1.5 | 1 |