Table 3 Individual LPV plasma concentrations in patients treated with RBT 150 mg TPW or RBT 300 mg TPW
Patients | Sex | Age (years) | Weight (kg) | C0 (µg/mL) | C1 | C2 | C3 | C4 | C6 | C8 | C12 | AUC0–12 (µg h/mL) | Cl (L/h/kg) | Cmax | Tmax |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
First group (RBT 150 mg TPW) | |||||||||||||||
Patient1 | F | 39 | 50.5 | 11.1 | 2.7 | 11.5 | 4.9 | 9.8 | 4.7 | 19.7 | 1 | 109.8 | 0.07 | 9.8 | 4 |
Patient3 | M | 36 | 56.8 | 18.3 | 15.3 | 21.4 | 20 | 13.6 | 9.2 | 8.9 | 10 | 151.3 | 0.05 | 21.4 | 2 |
Patient5 | M | 43 | 45.2 | 13 | 19.4 | 20 | 17.2 | 21.7 | 14 | 15.2 | 16.9 | 203.1 | 0.04 | 20 | 2 |
Patient7 | M | 32 | 44 | 13.3 | 11.7 | 11.6 | 12.3 | 16.4 | 23.7 | 21.6 | 15.7 | 111.8 | 0.08 | 23.7 | 6 |
Patient9 | F | 39 | 36 | 18.3 | 17.7 | 19.8 | 20.4 | 18.8 | 17.8 | 14.8 | 16.1 | 126.5 | 0.09 | 20.4 | 3 |
Patient11 | F | 33 | 57.6 | 7.5 | 8 | 10.3 | 10.8 | 11.5 | 10.7 | 8.2 | 8.3 | 67.4 | 0.11 | 11.5 | 4 |
Patient13 | M | 34 | 55 | 7.35 | 6.26 | 8.8 | 11.2 | 12.2 | 8.74 | 6.23 | 8.1 | 61.2 | 0.12 | 12.2 | 4 |
Patient15 | M | 24 | 52 | 22.1 | 23.2 | 20.4 | 20 | 18.3 | 25.7 | 23.7 | 16.2 | 150.4 | 0.05 | 25.7 | 6 |
Patient17 | M | 47 | 60 | 6.26 | 5.7 | 5.8 | 11 | 8.3 | 9.4 | 9 | 5.84 | 55.3 | 0.12 | 11 | 3 |
Second group (RBT 300 mg TPW) | |||||||||||||||
Patient2 | F | 33 | 40 | 0.01 | 1.1 | 5.6 | 13.7 | 15.1 | 10.2 | 9.1 | 4.4 | 99.5 | 0.10 | 15.1 | 4 |
Patient4 | M | 44 | 55 | 5.8 | 2.3 | 5 | 3.7 | 4.3 | 4.1 | 2.7 | 0.9 | 38.4 | 0.19 | 5 | 2 |
Patient6 | F | 33 | 40.1 | 1.62 | 1.82 | 4.36 | 5.85 | 6.8 | 7 | 7.7 | 4.9 | 69.9 | 0.14 | 7.7 | 8 |
Patient8 | M | 32 | 60.8 | 6 | 6 | 7.2 | 6.5 | 6.3 | 5.7 | 5 | 4.1 | 41.7 | 0.16 | 7.2 | 2 |
Patient10 | F | 32 | 40.2 | 0.01 | 8.7 | 22.3 | 23.9 | 19.2 | 14.3 | 12.8 | 7.3 | 104.9 | 0.09 | 23.9 | 3 |
Patient12 | F | 25 | 49.2 | 12.1 | 12.6 | 17.8 | 13.6 | 18.7 | 19.5 | 15.4 | 12.2 | 109.7 | 0.07 | 19.5 | 6 |
Patient14 | F | 44 | 52 | 6.6 | 5.1 | 4.42 | 4.7 | 3.94 | 2.7 | 1 | Low | 25.2 | 0.30 | 4.7 | 3 |