Fig. 2

Striking genus differences in urine microbiota composition between stone UR or tumor UR and controls. a The 44 different genus profiles of average relative abundance across three groups. C: control; S: stone UR; T: tumor UR. The dark green star indicates q < 0.01, light green star indicates q < 0.05, very light green star indicates p < 0.05, and gray star indicates q ≥ 0.05. b The relative abundance of 7 genera abundant in stone UR and tumor UR and 5 genera enriched in controls were exhibited with a box plot, respectively. c A network of Spearman’s correlation of the 44 significantly different genera among three groups. Blue edges, Spearman’s correlation coefficient < − 0.45; red edges, Spearman’s correlation coefficient > 0.45. d Heatmap of Spearman’s rank correlation coefficients of the relative abundance of different urine microbiota constituents at the genus level and 7 clinical indices. Genera that were enriched in controls are shown in blue. These asterisks indicate that the correlation is significant. GFR: glomerular filtration rate; ALP: alkaline phosphatase; DBIL: direct bilirubin; IBIL: indirect bilirubin; WBC: white blood cell count; UA: uric acid; RBC: red blood cell count