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Table 1 Antibiotic resistance rates and frequency of resistance genes among NDM positive and negative isolates

From: The emergence of the hypervirulent Klebsiella pneumoniae (hvKp) strains among circulating clonal complex 147 (CC147) harbouring blaNDM/OXA-48 carbapenemases in a tertiary care center of Iran

  NDM positive (n = 21) NDM negative (n = 101) NDM positive vs. NDM negative
P value
Resistance rates n (%)
 Imipenem 21 (100) 24 (23.8%) 0.001
 Meropenem 21 (100) 20 (19.8%) 0.001
 Ertapenem 21 (100) 30 (29.7%) 0.001
 Cefepime 20 (95.2) 39 (38.6%) 0.001
 Ceftazidime 21 (100) 52 (51.5%) 0.001
 Cefotaxime 21 (100) 66 (65.3%) 0.001
 Aztreonam 21 (100) 51 (50.5%) 0.001
 Ampicillin/sulbactam 21 (100) 54 (53.5%) 0.001
 Piperacillin/tazobactam 21 (100) 36 (35.3%) 0.001
 Amoxicillin/clavulanate 21 (100) 53 (52.5%) 0.001
 Ciprofloxacin 20 (95.2) 48 (47.5%) 0.001
 Levofloxacin 20 (95.2) 37 (36.6%) 0.001
 Gentamicin 20 (95.2) 28 (27.7%) 0.001
 Tobramycin 20 (95.2) 33 (32.7%) 0.001
 Amikacin 8 (38.1) 10 (9.9%) 0.003
 Trimethoprim/sulphamethoxazole 18 (85.7) 46 (45.5%) 0.001
 MDR 21 (100) 54 (53.5) 0.001
Presence of resistance and capsular markers n (%)
 armA 10 (47.6) 16 (15.8%) 0.003
 rmtC 3 (14.3) 3 (3%) 0.06*
 aac6Ib 14 (66.7) 35 (34.7%) 0.01
 aac3IIa 19 (90.5) 28 (27.5%) 0.001
 qnrB 1 (4.8) 22 (21.8%) 0.1
 qnrS 18 (85.7) 17 (16.8%) 0.001
 aac6Ib-cr 19 (90.5) 47 (47%) 0.001
 blaOXA-48 14 (66.7) 21 (20.8%) 0.001
 blaIMP- 0 3 (3%) 1
 CTX-M-G1 21 (100) 53 (52.5%) 0.001
 CTX-M-G2 0 3 (3%) 0.5
 CTX-M-G8 0 2 (2.0%) 0.6
 CTX-M-G9 0 2 (2.0%) 0.6
 CTX-M-G25 0 7 (7%) 0.2
 blaTEM- 12 (57.1) 29 (28.7%) 0.02
 blaSHV- 19 (90.5) 67 (66.3%) 0.03
 blaOXA-1 15 (71.4) 25 (24.8) 0.001
 K1 0 1 (1%) 1
 K2 0 15 (14.8) 0.07
  1. Italic values indicate the significance of P value (P < 0.05)
  2. MDR multidrug resistance
  3. *P value was borderline