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Table 1 Clinical and microbiological characteristics, host response and nutritional status of hvKp

From: Hypervirulent Klebsiella pneumoniae (hypermucoviscous and aerobactin positive) infection over 6 years in the elderly in China: antimicrobial resistance patterns, molecular epidemiology and risk factor

Characteristic HvKp (80) cKp (95) P value
K serotype
 K1 26 (32.5%) 3 (3.2%) 0.000
 K2 11 (13.8%) 1 (1.1%) 0.001
 K5 1 (1.3%) 0 (0%) 0.276
 K20 2 (2.5%) 5 (5.3%) 0.354
 K54 2 (2.5%) 3 (3.2%) 0.795
 K57 6 (7.5%) 7 (7.4%) 0.974
 rmpA 65 (81.3%) 17 (17.9%) 0.000
 rmpA2 58 (72.5%) 19 (20.0%) 0.000
 magA 63 (78.8%) 58 (61.1%) 0.012
Basic demographics
 Age 83.2 ± 8.75 86.2 ± 8.04 0.020
 Male 77 (96.3%) 92 (96.8%) 0.837
Underlying diseases
 Pulmonary disease 73 (91.3%) 90 (94.7%) 0.363
 Diabetes 61 (76.3%) 52 (54.7%) 0.003
 Cardiovascular disease 40 (50.0%) 58 (61.1%) 0.142
 Cerebrovascular disease 9 (11.3%) 20 (21.1%) 0.082
 Cancer 21 (26.3%) 28 (29.5%) 0.636
 Surgery within 1 mo 6 (7.5%) 11 (11.6%) 0.364
 Digestive disease 25 (31.3%) 20 (21.1%) 0.124
Catheter
 Central intravenous catheter 50 (62.5%) 65 (68.4%) 0.411
 Urinary catheter 57 (71.3%) 79 (83.2%) 0.059
 Tracheal catheter 24 (30.0%) 33 (34.7%) 0.505
 Stomach tube 45 (56.3%) 71 (74.7%) 0.01
 Drainage tube 4 (5.0%) 1 (1.1%) 0.119
Infection type
 HAP 62 (77.5%) 68 (71.6%) 0.372
 Urinary infection 8 (10.0%) 20 (21.1%) 0.047
 Invasive infection 23 (28.8%) 6 (6.3%) 0.000
  Bacteraemia 5 (6.3%) 4 (4.2%) 0.543
  Liver abscess 8 (10.0%) 1 (1.1%) 0.008
  Other abscess 13 (16.3%) 3 (3.2%) 0.003
 Abdominal infection 18 (22.5%) 6 (6.3%) 0.002
 Sepsis 41 (51.3%) 40 (42.1%) 0.227
 Septic shock 9 (11.3%) 3 (3.2%) 0.035
Host response
 WBC 12.87 ± 4.24 10.34 ± 2.95 0.000
 NEU% 78.87 ± 7.60 74.23 ± 7.83 0.000
Nutrition status
 TP 65.14 ± 4.93 62.96 ± 4.71 0.003
 ALB 35.54 ± 2.75 34.45 ± 3.44 0.021
SOFA score 6.84 ± 2.81 4.93 ± 2.59 0.000
Infection occurred in ICU 13 (16.3%) 14 (14.7%) 0.783
Relapse 5 (6.3%) 5 (5.3%) 0.779
Mortality at 28 days 14 (17.5%) 17 (17.9%) 0.946
  1. Underline values indicate statistical significance
  2. TP total protein, ALB albumin; HAP hospital acquired pneumonia, WBC white blood cell count, ESBLs extended spectrum beta lactamases, NEU% percentage of neutrophils