Appropriateness of empiric antimicrobial therapy with imipenem/colistin in severe septic patients: observational cohort study

Table 4 Factors associated with mortality by logistic regression

Varieties	Survivors (n = 46)	Died (n = 33)	OR [95% CI]	p
Inappropriate EAMT, n (%)	18 (39%)	20 (61%)	6.27 [1.83–21]	0.003
Age, mean ± DS^a	52 ± 18	54 ± 16	1.15 [0.28–4.64]	0.83
SOFA^a, mean ± DS	5.52	6.36	1.58 [0.79–2.91]	0.37
Chronic respiratory failure, n (%)	16 (35%)	11 (33%)	0.87 [0.35–2.15]	0.77
Cardiovascular disease, n (%)	19 (41%)	22 (66%)	1.43 [0.56–2.79]	0.25
Diabetes, n (%)	19 (41%)	12 (36%)	0.77 [0.27–1.96]	0.48
ICU acquired NI, n (%)	8 (17%)	15 (45%)	2.02 [1.37–12.12]	0.044
ED acquired NI, n (%)	20 (43%)	17 (51%)	1.16 [0.65–3.37]	0.67
Medical service acquired NI, n (%)	9 (19%)	4 (12%)	0.62 [0.01–1.84]	0.13
Shock, n (%)	11 (24%)	21 (63%)	1.96 [0.87–9.28]	0.09

EAMT, empiric antimicrobial therapy; SOFA, Sequential Organ Failure Assessment; ICU, intensive care unit; ED, emergency department; NI, nosocomial infection; OR, odds ratio; CI, confidence interval
^aStudied variables: age > 50 years and SOFA > 5
Italic values indicate p < 0.05

ISSN: 1476-0711