Table 4 Subgroup analysis of Colistin nephrotoxicity
Subgroup | Nephrotoxicity | Difference | 95% CI | P value | |
|---|---|---|---|---|---|
DM | Yes | No | − 0.05 | − 0.30 to 0.19 | 0.674 |
11 (36.7) | 13 (41.9) | ||||
Baseline Cr clearance (ml/min) | ≥ 50 | < 50 | 0.40 | 0.18 to 0.62 | 0.002 |
19 (57.6) | 5 (17.9) | ||||
Age | ≥ 65 | < 65 | 0.12 | − 0.13 to 0.37 | 0.348 |
12 (46.2) | 8 (38.1) | ||||
BMI | ≥ 30 | < 30 | − 0.02 | − 0.28 to 0.24 | 0.885 |
8 (38.1) | 16 (40.0) | ||||
APACHE 2 score | ≥ 20 | < 20 | − 0.22 | − 0.47 to 0.02 | 0.075 |
10 (29.4) | 14 (51.9) | ||||
Total daily dose | ≥ 300 mg | < 300 mg | 0.42 | 0.20 to 0.65 | 0.001 |
17 (63.0) | 7 (20.6) | ||||