Table 1 Dosing schedule for Colistin and Polymyxin B
Dosing schedule for Colistin in adults | ||
|---|---|---|
Renal function | Loading dose | Maintenance dose |
Normal renal function, or creatinine clearance > 50 ml/min | 5 mg/kg (or 150,000 U/kg) IV over 40–60 min | 2.5 mg/kg (or 75,000 U/kg) IV twice daily |
Creatinine clearance 20–50 ml/min | 2.5 mg/kg (or 75,000 U/kg) IV once daily | |
Creatinine clearance < 20 ml/min | 2.5 mg/kg (or 75,000 U/kg) IV on alternate days | |
Patient on hemodialysis | Give additional dose of 50 mg (15,00,000 U) post dialysis | |
Note | ||
1. Use ideal body weight for Colistin dosing, and not actual body weight | ||
2. Maintenance doses are started 12 h after loading dose | ||
Dosing schedule for Polymyxin B in adults | ||
|---|---|---|
Loading dose: 2.5 mg/kg as 2 h IV infusion Maintenance dose: 1.5 mg/kg as 1 h IV infusion, twice daily | ||
Note | ||
1. Use actual body weight for Polymyxin B dosing | ||
2. Maintenance doses are started 12 h after loading dose | ||
3. There is no dose modification in renal failure |