Fig. 3

Effect of biofilm presence on virus sensitivity to antiviral drugs. Antiviral effect of 50 µM acyclovir and 600 µM foscarnet on HSV-1 infected cells embedded or not in C. albicans biofilm. Twenty-four hours old Candida biofilms were co-cultured with HSV-1-infected VERO cells in medium containing acyclovir or foscarnet. After 24 h incubation, samples were frozen and thawed to lyse infected VERO, then the released virus was end-point titrated. Controls (no biofilm) were run in parallel. *p < 0.05