Voriconazole and posaconazole therapeutic drug monitoring: a retrospective study

Table 6 Variables independently associated with therapeutic drug levels

Variable	Multivariable logistic regression estimate	p	OR (95% CI)
Voriconazole
Total daily dose (mg)	0.001	0.64
mg/kg/dose	−0.79	0.33
mg/kg/day	0.44	0.29
Weight	−0.006	0.78
Concomitant H2RA/PPI	0.21	0.23	1.53 (0.77–3.09)
Critically ill	−0.06	0.67	0.88 (0.51–1.53)
Immunocompromised	0.002	0.99	1.003 (0.56–1.79)
Posaconazole
Total daily dose (mg)	0.009	0.07
mg/kg/dose	−0.076	0.74
mg/kg/day	−0.16	0.62
Weight	−0.015	0.65
Concomitant H2RA/PPI	−1.20	0.04	0.09 (0.007–0.75)
Critically ill	−0.34	0.43	0.05 (0.07–2.45)
Immunocompromised	−0.16	0.73	0.73 (0.11–4.53)

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