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Table 3 Detail of treatment failure episodes

From: High fluoroquinolone MIC is associated with fluoroquinolone treatment failure in urinary tract infections caused by fluoroquinolone susceptible Escherichia coli

Findings High MIC group Low MIC group
Patient-1 Patient-2 Patient-3 Patient-4
Type of UTIs Acute pyelonephritis Cystitis Cystitis Cystitis
First antibiotic prescription Levofloxacin 500 mg IV once daily for 4 days Ciprofloxacin 500 mg PO twice per day for 7 days Ciprofloxacin 500 mg PO twice per day for 5 days Levofloxacin 500 mg PO once daily for 7 days
Date of documented treatment failure (after the index date) Day-4 Day-9 Day-12 Day-8
Evidence of treatment failure Persistent fever on day-4
Levofloxacin was discontinued and IV cefipime was prescribed
Dysuria persisted on day- 9
Ciprofloxacin 500 mg PO bid for 7 days was prescribed on day-9
Dysuria persisted on day-12
Levofloxacin 500 mg PO od for 5 days was prescribed on day-12
Dysuria persisted on day-8
Nitrofurantoin 100 mg PO bid for 7 days was prescribed on day-8
Repeated urine culture No No Yes (on day-12)
Culture: no growth
No