Table 3 Detail of treatment failure episodes
Findings | High MIC group | Low MIC group | ||
|---|---|---|---|---|
Patient-1 | Patient-2 | Patient-3 | Patient-4 | |
Type of UTIs | Acute pyelonephritis | Cystitis | Cystitis | Cystitis |
First antibiotic prescription | Levofloxacin 500 mg IV once daily for 4 days | Ciprofloxacin 500 mg PO twice per day for 7 days | Ciprofloxacin 500 mg PO twice per day for 5 days | Levofloxacin 500 mg PO once daily for 7 days |
Date of documented treatment failure (after the index date) | Day-4 | Day-9 | Day-12 | Day-8 |
Evidence of treatment failure | Persistent fever on day-4 Levofloxacin was discontinued and IV cefipime was prescribed | Dysuria persisted on day- 9 Ciprofloxacin 500 mg PO bid for 7 days was prescribed on day-9 | Dysuria persisted on day-12 Levofloxacin 500 mg PO od for 5 days was prescribed on day-12 | Dysuria persisted on day-8 Nitrofurantoin 100 mg PO bid for 7 days was prescribed on day-8 |
Repeated urine culture | No | No | Yes (on day-12) Culture: no growth | No |