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Table 1 PBP genotypes and serotypes distribution of the 80 penicillin non-susceptible Streptococcus pneumoniae isolated from invasive diseases in Casablanca, Morocco (2007–2014)

From: Molecular characterization of penicillin non-susceptible Streptococcus pneumoniae isolated before and after pneumococcal conjugate vaccine implementation in Casablanca, Morocco

Genotype of pbp genes Number of strains MIC for PG (mg/L) Serotype (number of strains)
pbp1a pbp2b pbp2x
Pre-vaccination period
1 3 7 1 1 23F (1)
1 5 7 6 0.25–2 23F (2), 14 (2), 23A (1), 5 (1)
1 5 1 3 1–2 14 (3)
1 7 7 1 2 9V (1)
1 9 6 1 2 14 (1)
2 4 6 1 2 14 (1)
2 5 7 4 0.52 14 (4)
2 5 12 1 0.5 14 (1)
2 5 8 1 2 19F (1)
2 5 1 1 2 14 (1)
2 7 8 2 0.52 6B (2)
2 8 1 2 0.5–2 19F (2)
3 6 9 1 0.25 23F (1)
4 2 5 17 0.125–0.5 19A (16), 19F (1)
4 2 2 4 0.5–1 24 (1) NT(2) 19F (1)
4 7 7 3 0.5 NT (3)
5 6 11 1 0.125−0.5 23F (1)
6 3 3 2 0.125−0.25 6B (2)
6 10 4 3 0.25 NT (3)
8 9 10 1 0.25 6A (1)
10 11 11 1 0.25 18C (1)
Post-vaccination period
1 1 1 1 2 14 (1)
1 5 1 1 2 14 (1)
2 8 1 1 0.5 19F (1)
4 2 2 6 0.25−0.5 NT (3), 7F (1), 7A (2)
6 3 3 2 0.125−1 6B (1), 6A (1)
1 4 6 1 2 14 (1)
4 2 5 2 0.25 19A (2)
1 5 6 1 2 14 (1)
1 5 7 5 0.5–1 14 (5)
5 2 11 1 0.25 23F (1)
2 5 12 1 2 14 (1)
7 6 13 1 0.125 22F (1)
  1. MIC minimal inhibitory concentration, PG penicillin G, pbp penicillin binding protein gene
  2. Genotypes written in italics are those selected for PFGE typing