Table 1 PBP genotypes and serotypes distribution of the 80 penicillin non-susceptible Streptococcus pneumoniae isolated from invasive diseases in Casablanca, Morocco (2007–2014)
Genotype of pbp genes | Number of strains | MIC for PG (mg/L) | Serotype (number of strains) | ||
|---|---|---|---|---|---|
pbp1a | pbp2b | pbp2x | |||
Pre-vaccination period | |||||
1 | 3 | 7 | 1 | 1 | 23F (1) |
1 | 5 | 7 | 6 | 0.25–2 | 23F (2), 14 (2), 23A (1), 5 (1) |
1 | 5 | 1 | 3 | 1–2 | 14 (3) |
1 | 7 | 7 | 1 | 2 | 9V (1) |
1 | 9 | 6 | 1 | 2 | 14 (1) |
2 | 4 | 6 | 1 | 2 | 14 (1) |
2 | 5 | 7 | 4 | 0.5–2 | 14 (4) |
2 | 5 | 12 | 1 | 0.5 | 14 (1) |
2 | 5 | 8 | 1 | 2 | 19F (1) |
2 | 5 | 1 | 1 | 2 | 14 (1) |
2 | 7 | 8 | 2 | 0.5–2 | 6B (2) |
2 | 8 | 1 | 2 | 0.5–2 | 19F (2) |
3 | 6 | 9 | 1 | 0.25 | 23F (1) |
4 | 2 | 5 | 17 | 0.125–0.5 | 19A (16), 19F (1) |
4 | 2 | 2 | 4 | 0.5–1 | 24 (1) NT(2) 19F (1) |
4 | 7 | 7 | 3 | 0.5 | NT (3) |
5 | 6 | 11 | 1 | 0.125−0.5 | 23F (1) |
6 | 3 | 3 | 2 | 0.125−0.25 | 6B (2) |
6 | 10 | 4 | 3 | 0.25 | NT (3) |
8 | 9 | 10 | 1 | 0.25 | 6A (1) |
10 | 11 | 11 | 1 | 0.25 | 18C (1) |
Post-vaccination period | |||||
1 | 1 | 1 | 1 | 2 | 14 (1) |
1 | 5 | 1 | 1 | 2 | 14 (1) |
2 | 8 | 1 | 1 | 0.5 | 19F (1) |
4 | 2 | 2 | 6 | 0.25−0.5 | NT (3), 7F (1), 7A (2) |
6 | 3 | 3 | 2 | 0.125−1 | 6B (1), 6A (1) |
1 | 4 | 6 | 1 | 2 | 14 (1) |
4 | 2 | 5 | 2 | 0.25 | 19A (2) |
1 | 5 | 6 | 1 | 2 | 14 (1) |
1 | 5 | 7 | 5 | 0.5–1 | 14 (5) |
5 | 2 | 11 | 1 | 0.25 | 23F (1) |
2 | 5 | 12 | 1 | 2 | 14 (1) |
7 | 6 | 13 | 1 | 0.125 | 22F (1) |