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Table 2 Values (median) of DOT and DDD in bloodstream infections treatment according to etiological factors

From: Antibiotic consumption in laboratory confirmed vs. non-confirmed bloodstream infections among very low birth weight neonates in Poland

Etiology

DOT (days)

DDD

Median (IQR)

Median (IQR)

Gram+ N = 452

 Aminoglycosides

7.0 (5.0; 9.0)

0.109 (0.560; 0.180)

 Antimycotics

12.0 (9.3; 16.0)

0.195 (0.131; 0.341)

 Beta-lactams

7.0 (5.0; 10.0)

0.252 (0.180; 0.420)

 Glycopeptides

10.0 (8.0; 11.0)

0.128 (0.088; 0.168)

 Other

9.0 (5.0; 15.0)

0.211 (0.096; 0.452)

 Total

9.0 (5.0; 15.0)

0.140 (0.056; 0.453)

Gram− N = 103

 Aminoglycosides

6.0 (4.3; 8.0)

0.056 (0.036; 0.137)

 Antimycotics

12.0 (8.2; 17.0)

0.228 (0.131; 0.360)

 Beta-lactams

8.0 (4.0; 11.0)

0.244 (0.096; 0.448)

 Glycopeptides

8.0 (4.0; 9.0)

0.098 (0.039; 0.149)

 Other

8.5 (5.3; 10.8)

0.229 (0.099; 0.608)

 Total

7.5 (4.0; 17.0)

0.136 (0.036; 0.447)

Changing N = 76

 Aminoglycosides

7.0 (5.0; 10.0)

0.105 (0.061; 0.180)

 Antimycotics

12.0 (10.0; 16.0)

0.250 (0.158; 0.735)

 Beta-lactams

7.0 (6.5; 11.0)

0.281 (0.169; 0.495)

 Glycopeptides

10.0 (7.0; 11.0)

0.085 (0.056; 0.167)

 Other

9.0 (6.0; 14.5)

0.187 (0.120; 2.580)

 Total

9.0 (5.0; 16.0)

0.149 (0.056; 2.580)

Candida N = 18

 Aminoglycosides

8.5 (4.8; 12.8)

0.140 (0.070; 0.210)

 Antimycotics

10.5 (9.0; 15.8)

0.225 (0.092; 0.353)

 Beta-lactams

12.0 (9.0; 19.5)

450 (192.9; 2175)

 Glycopeptides

10.0 (7.3; 10.8)

0.087 (0.063; 0.161)

 Other

13.5 (10.0; 17.0)

3.276 (0.153; 6.400)

 Total

10.0 (4.8; 19.5)

0.164 (0.063; 6.400)

  1. Changing—when, during treatment, positive microbiological cultures were obtained from different samples, or samples taken at different times (within 5 days), growth of microorganisms belonging to various groups (e.g. Escherichia coli and Candida albicans) was defined as cases of changing etiology (group “changing”)
  2. DOT days of therapy (per one case), DDD defined daily dose (per one case), IQR interquartile range, N number of cases