Recurrent Scedosporium apiospermum mycetoma successfully treated by surgical excision and terbinafine treatment: a case report and review of the literature

Tóth, Eszter J.; Nagy, Géza R.; Homa, Mónika; Ábrók, Marianna; Kiss, Ildikó É.; Nagy, Gábor; Bata-Csörgő, Zsuzsanna; Kemény, Lajos; Urbán, Edit; Vágvölgyi, Csaba; Papp, Tamás

doi:10.1186/s12941-017-0195-z

Annals of Clinical Microbiology and Antimicrobials

Table 2 Subcutaneous infections caused by Scedosporium species in Europe since 1990

From: Recurrent Scedosporium apiospermum mycetoma successfully treated by surgical excision and terbinafine treatment: a case report and review of the literature

Age, gender	Immune status	Predisposing conditions	Signs, symptoms	Aetiological agent	Site of infection	Therapy	Outcome	References
The Netherlands
59, M	Immunosupp.	Renal transplantation, IV catheter	Purple nodules, slight desquamation	S. apiospermum	Left hand and lower arm	VRC	Recovered	[14]
84, M	Immunosupp.	COPD, Periprosthetic fracture	Inflammation with bullae	S. apiospermum	Right elbow	VRC	Death after good initial response	[14]
Germany
24, M	Immunocomp.	Fracture of the tibia	Edematous swellings	S. boydii, Nocardia abscessus	Lower left leg	ITC	Recovered	[15]
58, M	Immunosupp.	Chronic glomerulonephritis, Renal transplantation, Insect sting	Painful, swollen induration	S. apiospermum	Right forefoot	MCZ, Vacuum seal and suction technique	Recovered	[16]
15, M	Immunosupp.	Lupus erythematodes, Tibia and fibula fracture	Swelling, impaired wound healing	S. boydii	Lower leg	VRC	Recovered	[17]
53, F	Immunosupp.	AML	Reddish, inflammatory, painless tumor with central necrosis	S. apiospermum	Right forearm	CSP, VRC	Recovered	[18]
Spain
58, M	Immunosupp.	Chronic glomerulonephritis	Fever, cutaneous lesions	S. apiospermum	Both legs	VRC	Recovered	[19]
51, M	Immunosupp.	Renal transplantation	Nodular lesions	S. apiospermum	Left heel	ITC, SI	Recovered	[20]
France
79, M	Immunosupp.	Bronchospasm	Fever, bullous and necrotic purpura	S. apiospermum	n.a.	ITC	Death (due to Pseudomonas lung infection)	[21]
65, M	Immunosupp.	COPD, IV catheter	Purple nodules, slight desquamation	S. apiospermum	Left wrist and lower arm	VRC	Recovered	[22]
UK
51, M	Immunocomp.	Stepped in a dung fork	Swollen, painful foot	S. boydii	Foot (bone involvement)	ITC	Recovered	[23]
71, M	Immunosupp.	AML	Painful, swollen, erythematous foot, necrotic ulcer between toes	S. apiospermum	Right foot	ITC	Recovered	[24]
81, M	Immunosupp.	Renal impairment, Pulmonary fibrosis, Scratch from a bush.	Tender subcutaneous nodules	S. apiospermum	Left forearm (joint involvement)	ITC	No follow up	[25]
35, M	Immunocomp.	na	Painless swelling	S. apiospermum	Right ankle	VRC	Recovered	[26]
Italy
59, F	Immunosupp.	Renal transplantation	Pain, Achilles tendonitis	S. apiospermum	Skin, knee, and Achilles tendon of the left leg	VRC	Recovered	[27]
Serbia
50, F	Immunocomp.	na	Pain, indurations, local redness	S. boydii	Soft tissue and bone involvement	SI	Recovered	[28]
Slovenia
64, M	Immunosupp.	Microscopic polyangiitis	Swelling, pain	S. boydii	Left leg and foot	VRC	Recovered	[29]
Turkey
48, M	Immunocomp.	na	Swelling	Bacteria, S. boydii	Right hand	Amputation	Recovered	[30]
62, F	Immunosupp.	Renal transplantation	Edema, erythema, painful, indurated lesion	S. boydii	Left leg	ITC	Recovered	[31]
Hungary
63, M	Immunosupp.	AML	Swelling, tenderness	S. apiospermum	Lower left leg	ITC	Recovered	[32]
70, M	Immunosupp.	Nephrotic syndrome	Pain, edema, fever, erythema	S. apiospermum	Lower right leg and foot	TRB, SI	Recovered	Present case

AML acute myeloid leukemia, COPD chronic obstructive pulmonary disease, CSP caspofungin, F female, Immunocomp. immunocompetent, Immunosupp. immunosuppressed, ITC itraconazole, IV intravenous, M male, MCZ miconazole, na not available, SI surgical intervention, TRB terbinafine, VRC voriconazole

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ISSN: 1476-0711

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