Table 4 Antimicrobial activity of AMP2041 against PA isolates
Reference number | Human clinical isolates LD90 [μg/ml] | Cystic fibrosis isolates LD90 [μg/ml] | Animal clinical isolates LD90 [μg/ml] |
|---|---|---|---|
[1] | 3.02 | 0.3 | 1.09 |
[2] | 1.03 | 10.4 | 8.30 |
[3] | 0.6 | 4.5 | 0.77 |
[4] | 1.14 | 3.8 | 0.93 |
[5] | 0.18 | 3.2 | 2.91 |
[6] | 6.07 | – | 2.87 |
[7] | 7.78 | – | 2.94 |
[8] | 3.77 | – | 1.75 |
[9] | 3.63 | – | 1.75 |
[10] | 0.97 | – | 0.94 |
[11] | 2.14 | – | 2.80 |
[12] | 6.15 | – | 0.99 |
[13] | 0.95 | – | 2.33 |
[14] | 5.04 | – | 1.41 |
[15] | – | – | 1.06 |
[16] | – | – | 1.16 |
[17] | – | – | 1.01 |
[18] | – | – | 0.56 |
[19] | – | – | 0.77 |
[20] | – | – | 0.63 |
[21] | – | – | 1.39 |
[22] | – | – | 0.98 |
[23] | – | – | 1.14 |
[24] | – | – | 0.36 |
[25] | – | – | 2.15 |
[26] | – | – | 0.53 |
[27] | – | – | 2.87 |
[28] | – | – | 2.80 |
[29] | – | – | 0.51 |
[30] | – | – | 0.83 |
Mean ± SD [95% CI] | 3.3 ± 2.44 [1.75–4.31] | 4.44 ± 3.31 [1.54–7.34] | 1.69 ± 1.5 [1.14–2.25] |