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Table 1 Description of the characteristics of included studies

From: Efficacy and safety profile of linezolid in the treatment of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis: a systematic review and meta-analysis

Study No. Reference Year of publication Country of study Study design Control group Number exposed to Linezolid Study duration Number of XDR-TB LZD dosage Duration of LZD treatment Type of anti-TB regimen HIV infection status
1. Abbate et al.[35] 2012 Argentina Retrospective study No 17 2002–2008 17 600 mg bd ≥12 months after cc Individualized All HIV negative
2. Anger et al. [36] 2010 USA Retrospective case series No 16 2000–2006 10 600 mg bd 400 mg bd or 600 mg daily Mean = 15 Median = 16 Range = 1–29 months Individualized 3 HIV positive
3. Condos et al.[37] 2008 USA Prospective phase 1 clinical trial No 6a 2000–2007 6a 600 mg bd 600 mg daily Range = 9–26 months Individualized All HIV negative
4. De Lorenzo et al. [38] 2012 Italy Retrospective study No 12 2009–2010 4 600 mg bd (10 patients) 600 mg daily (1 patient) 450 mg bd (1 patient) Range = 37–100 days Median = 63.5 days Individualized 2 HIV negative
5. Fortún et al. [39] 2005 Spain Retrospective case series No 3b 1994–2004 0 600 mg bd Range = 4–24 months Mean = 12 Median = 12 Individualized 1 HIV positive
6. Koh et al. [40] 2009 South Korea Retrospective case series No 24 2007–2008 1 300 mg daily Median = 12 months Individualised All HIV Negative
7. Koh et al. [41] 2012 South Korea Retrospective case series No 51 2007–2009 26 300 mg daily Median = 413 days IQR = 237–622 days Individualized All HIV negative
8. Lee et al. [42] 2012 South Korea Phase 2a randomized two-group study No 38 2008–2011 41 600 mg daily 22 months Individualized All HIV negative
9. Liu et al. [43] 2015 China Retrospective case series No 16 2011–2013 16 600 mg daily Range = 3–21 months Mean = 9.53 months Individualized All HIV negative
10. Migliori et al. [44] 2009 Belarus, Germany, Italy, Switzerland Retrospective non-randomized unblinded observational study Yes 85 2001–2007 12 600 mg daily 600 mg bd Mean = 7 months Median = 3 months Individualized 3 HIV positive
11. Nam et al. [45] 2009 South Korea Retrospective case series No 11 NR 4 600 mg daily 300 mg bd Range 3–24 months Mean = 7 months Median 5 months Individualized All HIV negative
12. Park et al. [46] 2006 South Korea Prospective non-randomized case series No 8 2003–2006 5 600 daily 600 bd Range = 3–18 months Median = 9 months Mean = 11 months Individualized All HIV negative
13. Roongruangpitayakul et al. [47] 2013 Thailand Retrospective case series No 24 2009–2012 7 600 mg daily 300 mg daily Range = 11.0–21.5 months Mean = 18.7 months Individualized All HIV negative
14. Schecter et al. [48] 2010 USA Retrospective case series No 30 2003–2007 3 600 mg daily Range = 1–36 months Median = 22 months Mean = 19 months Individualized 17 HIV negative
15. Singla et al. [49] 2012 India Prospective case series No 29 2006–2011 16 600 bd 600 daily Median = 30 days Individualized All HIV negative
16. Tang et al. [50] 2011 China Case series No 14 2009–2010 14 600 mg bd 600 mg daily Range= 2–11 months Mean: 6.5 months Individualised All HIV negative
17. Tang et al. [51] 2015 China Prospective multicenter randomized controlled study Yes 33 2009–2011 65 1200 mg daily 300–600 mg daily Range = 2–24 months Individualized All HIV negative
18. Tse-Chang et al. [52] 2013 Canada Retrospective case study No 13 2000–2011 NR 600 mg daily Mean = 8.3 months Range = 1.4–22 months Individualized 1 HIV positive
19. Udwadia et al. [53] 2010 India Prospective non-randomized case series No 18 2000–2007 7 600 mg daily Mean = 21 months Individualized NR
20. Villar et al. [54] 2011 Portugal Prospective case series No 16 2004–2009 12 600 daily 1200 mg daily Median = 375 days Individualized 6 HIV positive
21. Von der Lippe et al. [55] 2006 Norway Retrospective case series No 10 1998–2002 0 600 mg bd Range = 2–10 months Median = 4.25 months Individualized 1HIV positive
22. Xu et al. [56] 2012 China Retrospective case series No 18 2007–2010 15 600 mg bd 900 mg daily Range =1.5–10 months Median = 6 months Individualized All HIV negative
23. Zhang et al. [57] 2014 China Retrospective study Yes 15 2012–2013 43 600 mg daily Range = 1–5 months Individualized All HIV negative
  1. a One paediatric case excluded
  2. b Excluded two patients with M. bovis infection