Chemical structure and pharmacokinetics of novel quinolone agents represented by avarofloxacin, delafloxacin, finafloxacin, zabofloxacin and nemonoxacin

Kocsis, Bela; Domokos, J.; Szabo, D.

doi:10.1186/s12941-016-0150-4

Annals of Clinical Microbiology and Antimicrobials

Table 2 Quinolone MIC values of medically relevant pathogens

From: Chemical structure and pharmacokinetics of novel quinolone agents represented by avarofloxacin, delafloxacin, finafloxacin, zabofloxacin and nemonoxacin

Organism	Antibacterial agents	MIC range	MIC₉₀	Ref.
S. pneumoniae	Avarofloxacin	0.06–0.5	0.25	[10]
	ciprofloxacin	8–64	64	[10]
	Delafloxacin	n.a.	n.a.	n.a.
	Finafloxacin	0.5–4	2	[41]
	Zabofloxacin	0.015–0.06	0.03	[24]
	Nemonoxacin	0.03–1	0.06	[34]
S. aureus, MRSA FQ-resistant	Avarofloxacin	0.015–2	0.25	[10]
	Ciprofloxacin	4 ≥ 256	64	[10]
	Delafloxacin	≤0.004–0.12	0.06	[15]
	Finafloxacin	0.25–32	4	[41]
	Zabofloxacin	0.016–64	32	[26]
	Nemonoxacin	0.5–1	1	[34]
S. aureus, MRSA FQ-susceptible	Avarofloxacin	0.008–0.015	0.008	[42]
	Ciprofloxacin	0.25–1	0.5	[42]
	Delafloxacin	0.008–1	0.5	[13]
	Finafloxacin	0.06–0.125	0.125	[41]
	Zabofloxacin	0.016–1	0.125	[26]
	Nemonoxacin	≤0.008–0.12	0.06	[31]
E. faecalis	Avarofloxacin	0.03–1	0.5	[10]
	Ciprofloxacin	0.5–>16	>16	[10]
	Delafloxacin	n.a.	n.a.	n.a.
	Finafloxacin	1–2	n.a.	[22]
	Zabofloxacin	0.008 ≥ 4	2	[24]
	Nemonoxacin	0.12–8	4	[34]
E. faecium	Avarofloxacin	0.25–4	4	[10]
	Ciprofloxacin	1 ≥ 16	>16	[10]
	Delafloxacin	n.a.	n.a.	n.a.
	Finafloxacin	n.a.	n.a.	n.a.
	Zabofloxacin	2–32	16	[24]
	Nemonoxacin	0.06–16	16	[34]
E. coli	Avarofloxacin	1–16	16	[10]
	Ciprofloxacin	16 ≥ 256	256	[10]
	Delafloxacin	2–128	n.a.	[43]
	Finafloxacin	16 ≥ 256	256	[41]
	Zabofloxacin	0.015–64	1	[24]
	Nemonoxacin	0.5–32	32	[31]
K. pneumoniae	Avarofloxacin	≤0.015–1	0.25	[10]
	Ciprofloxacin	≤0.004–1	0.25	[10]
	Delafloxacin	n.a.	n.a.	n.a.
	Finafloxacin	0.015–0.6	n.a.	[22]
	Zabofloxacin	0.06–8	1	[24]
	Nemonoxacin	0.5–32	2	[31]
P. aeruginosa	Avarofloxacin	0.5–4	2	[10]
	Ciprofloxacin	0.12–1	0.5	[10]
	Delafloxacin	0.016–1	n.a.	[43]
	Finafloxacin	0.25–8	2	[41]
	Zabofloxacin	<0.008 ≥ 64	>64	[24]
	Nemonoxacin	0.12–32	32	[31]
H. influenzae	Avarofloxacin	0.008–0.015	0.015	[10]
	Ciprofloxacin	0.008–0.015	0.015	[10]
	Delafloxacin	n.a.	n.a.	n.a.
	Finafloxacin	n.a.	n.a.	n.a.
	Zabofloxacin	<0.008–0.008	0.008	[24]
	Nemonoxacin	≤0.008–0.06	n.a.	[38]

All values are in mg/L
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