Table 1 Drug resistance profiles and resistance mechanisms of NDM-1-producing K. pneumoniae
Strains | Organism | Source | NDM | IMP | CTX | SHV | TEM | QnrB | qnrS | aac | MICs, μg/mL | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
MEM | IPM | CAZ | FOX | AMK | TIG | PIP | PIP/TZB | ATM | LEV | |||||||||||
M1 | KPN | Sputum | NDM-1 | – | CTX-M-15 | SHV-1 | TEM-1 | – | – | – | 128 | 32 | >128 | >128 | 1 | 0.25 | >128 | >128/4 | >128 | <0.06 |
M2 | KPN | Stool | NDM-1 | – | CTX-M-15 | SHV-1 | – | qnrB4 | – | aacA4 | 64 | 32 | >128 | >128 | 2 | 0.25 | >128 | >128/4 | 4 | 0.25 |
M3 | KPN | Stool | NDM-1 | IMP-4 | CTX-M-15 | SHV-1 | – | – | qnrS1 | aacA4 | 64 | 16 | >128 | >128 | 1 | 0.25 | >128 | >128/4 | 8 | <0.06 |
M4 | KPN | Stool | NDM-1 | – | CTX-M-15 | SHV-1 | – | qnrB4 | qnrS1 | aacA4 | 128 | 32 | >128 | >128 | 2 | 0.25 | >128 | >128/4 | 4 | <0.06 |
M5 | KPN | Stool | NDM-1 | IMP-4 | CTX-M-15 | SHV-1 | – | qnrB4 | qnrS1 | aacA4 | 128 | 16 | >128 | >128 | 1 | 0.25 | >128 | >128/4 | 32 | <0.06 |
M6 | KPN | Stool | NDM-1 | – | CTX-M-15 | SHV-1 | – | – | – | – | 64 | 16 | >128 | >128 | 2 | 0.25 | >128 | >128/4 | 4 | <0.06 |
M7 | KPN | Blood | NDM-1 | – | CTX-M-15 | SHV-1 | – | – | – | – | 64 | 16 | >128 | >128 | 1 | 0.25 | >128 | >128/4 | 8 | 0.25 |
M8 | KPN | Blood | NDM-1 | IMP-4 | CTX-M-15 | SHV-1 | – | – | qnrS1 | – | 64 | 16 | >128 | >128 | 1 | 0.25 | >128 | >128/4 | 16 | <0.06 |
M9 | KPN | Sputum | NDM-1 | IMP-4 | CTX-M-15 | SHV-1 | – | – | qnrS1 | aacA4 | 64 | 32 | >128 | >128 | 1 | 0.25 | >128 | >128/4 | 8 | <0.06 |
M10 | KPN | Stool | NDM-1 | – | CTX-M-15 | SHV-1 | – | – | – | – | 64 | 32 | >128 | >128 | 1 | 0.25 | >128 | >128/4 | 4 | <0.06 |
M11 | KPN | Stool | NDM-1 | – | CTX-M-15 | SHV-1 | – | – | qnrS1 | aacA4 | 32 | 4 | >128 | >128 | 1 | 0.5 | >128 | >128/4 | 4 | <0.06 |
M12 | KPN | Stool | NDM-1 | – | CTX-M-15 | SHV-1 | – | qnrB4 | qnrS1 | – | 64 | 16 | >128 | >128 | 1 | 0.5 | >128 | >128/4 | 64 | <0.06 |
M13 | KPN | Stool | NDM-1 | – | CTX-M-15 | SHV-1 | – | qnrB4 | qnrS1 | – | 64 | 128 | >128 | >128 | 1 | 1 | >128 | >128/4 | 32 | <0.06 |
M14 | KPN | Blood | NDM-1 | – | CTX-M-15 | SHV-1 | – | qnrB4 | – | – | 64 | 32 | >128 | >128 | 1 | 0.25 | >128 | >128/4 | 16 | <0.06 |
M15 | KPN | Blood | NDM-1 | – | CTX-M-15 | SHV-1 | – | qnrB4 | – | – | 64 | 32 | >128 | >128 | 1 | 0.25 | >128 | >128/4 | 4 | <0.06 |
M16 | KPN | Stool | NDM-1 | – | CTX-M-15 | SHV-1 | – | qnrB4 | – | aacA4 | 64 | >128 | >128 | >128 | 8 | 0.5 | >128 | >128/4 | 16 | 8 |
M17 | KPN | Sputum | NDM-1 | IMP-4 | CTX-M-15 | SHV-1 | – | qnrB4 | qnrS1 | aacA4 | 128 | 16 | >128 | >128 | 1 | 0.5 | >128 | >128/4 | 32 | <0.06 |
M18 | KPN | Sputum | NDM-1 | IMP-4 | CTX-M-15 | SHV-1 | – | qnrB4 | qnrS1 | aacA4 | 64 | 16 | >128 | >128 | 1 | 0.5 | >128 | >128/4 | 32 | <0.06 |
M19 | KPN | iw | NDM-1 | IMP-4 | CTX-M-15 | SHV-1 | – | qnrB4 | qnrS1 | aacA4 | 64 | 32 | >128 | >128 | 1 | 0.5 | >128 | >128/4 | 16 | <0.06 |