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Table 2 Synergism activity between compounds 1 and 2 with amphotericin B, trimethoprim-sulfamethoxazole and itraconazole against Paracocidioides brasiliensis (isolate Pb18).

From: Antifungal activity of schinol and a new biphenyl compound isolated from Schinus terebinthifolius against the pathogenic fungus Paracoccidioides brasiliensis

Combination

FIC

Compound 2 + amphotericin B

1 (I)1

Compound 2 + trimethoprim-sulfamethoxazole

1.5 (I)1

Compound 2 + itraconazole

1 (I)1

Compound 1 + amphotericin B

1 (I)1

Compound 1 + trimethoprim-sulfamethoxazole

1.5 (I)1

Compound 1 + itraconazole

0.5 (S)1

  1. 1S, synergy; I, no effect; A, antagonism
  2. Compound 1: schinol, compound 2: 4'-ethyl-4-methyl-2,2',6,6'-tetrahydroxy [1,1'-biphenyl]-4,4'-dicarboxylate
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Annals of Clinical Microbiology and Antimicrobials

ISSN: 1476-0711

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