From: Evaluating antibiotics for use in medicine using a poloxamer biofilm model
ANTIBIOTIC | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
BACTERIA | Test Method [mm] | Amoxycillin/Clavulanic acid | Ampicillin/Sulbactam | Ampicillin/Sulbactam | Ciprofloxacin | Clindamycin | Erythromycin | Erythromycin | Imipenem | Levofloxacin | Meropenem | Penicillin G |
30 μg | 20 μg | 30 μg | 5 μg | 10 μg | 15 μg | 30 μg | 10 μg | 5 μg | 10 μg | 5 IU | ||
Bacillus cereus | Agar | 13.87 ± 0.24 | 13.20 ± 0.00 | 14.93 ± 0.24 | 25.47 ± 0.07 | 25.73 ± 0.18 | 28.80 ± 0.23 | 30.07 ± 0.13 | 33.00 ± 0.64 | 24.87 ± 0.18 | 31.27 ± 0.68 | 7.07 ± 0.07 |
Poloxamer | 11.60 ± 0.00 | 11.80 ± 0.00 | 12.33 ± 0.13 | 17.13 ± 0.33 | 15.40 ± 0.23 | 16.73 ± 0.18 | 18.13 ± 0.07 | 22.40 ± 1.11 | 18.00 ± 0.12 | 22.33 ± 0.18 | 0.00 ± 0.00 | |
Bacillus licheniformis | Agar | 25.87 ± 0.24 | 23.47 ± 0.66 | 25.73 ± 0.13 | 34.67 ± 0.84 | 0.00 ± 0.00 | 30.80 ± 0.20 | 31.27 ± 0.55 | 39.27 ± 0.18 | 33.33 ± 0.18 | 41.53 ± 0.07 | 0.00 ± 0.00 |
Poloxamer | 18.13 ± 0.13 | 17.40 ± 0.00 | 18.20 ± 0.20 | 22.70 ± 0.32 | 8.73 ± 0.13 | 16.33 ± 0.07 | 17.53 ± 0.07 | 27.40 ± 0.12 | 21.60 ± 0.23 | 23.47 ± 0.18 | 9.40 ± 0.20 | |
Corynebacterium pseudotuberculosis | Agar | NM | NM | NM | NM | NM | NM | NM | NM | NM | NM | NM |
Poloxamer | 29.87 ± 0.13 | 27.33 ± 0.29 | 28.93 ± 0.47 | 31.53 ± 0.59 | 18.13 ± 0.18 | 25.87 ± 0.48 | 26.40 ± 0.64 | 35.33 ± 0.55 | 28.93 ± 1.23 | 30.13 ± 0.64 | 22.73 ± 0.29 | |
Corynebacterium renale | Agar | NM | NM | NM | NM | NM | NM | NM | NM | NM | NM | NM |
Poloxamer | 32.47 ± 0.75 | 31.20 ± 0.23 | 31.00 ± 0.69 | 20.20 ± 0.12 | 19.07 ± 0.35 | 22.33 ± 0.18 | 24.00 ± 0.00 | 35.53 ± 0.13 | 19.40 ± 0.00 | 30.47 ± 0.27 | 25.40 ± 0.31 | |
Enterococcus faecalis | Agar | 31.67 ± 0.13 | 27.07 ± 0.13 | 29.20 ± 0.00 | 20.87 ± 0.07 | 12.00 ± 0.20 | 24.53 ± 0.18 | 25.53 ± 0.24 | 29.67 ± 0.47 | 22.13 ± 0.24 | 23.27 ± 0.27 | 20.13 ± 0.64 |
Poloxamer | 16.80 ± 0.20 | 17.13 ± 0.24 | 18.60 ± 0.12 | 13.53 ± 0.18 | 8.20 ± 0.12 | 10.00 ± 0.20 | 10.47 ± 0.18 | 19.27 ± 0.18 | 13.13 ± 0.18 | 15.73 ± 0.13 | 12.27 ± 0.13 | |
Listeria ivanovii | Agar | 11.07 ± 0.27 | 7.20 ± 0.00 | 7.73 ± 0.07 | 36.07 ± 0.29 | 7.27 ± 0.07 | 9.87 ± 0.07 | 11.80 ± 0.83 | 36.60 ± 0.69 | 28.27 ± 0.47 | 25.40 ± 0.40 | 7.40 ± 0.12 |
Poloxamer | 8.67 ± 0.13 | 7.20 ± 0.00 | 7.20 ± 0.00 | 22.07 ± 0.41 | 7.20 ± 0.00 | 8.73 ± 0.07 | 8.67 ± 0.07 | 22.67 ± 0.07 | 20.73 ± 0.13 | 19.47 ± 0.41 | 0.00 ± 0.00 | |
Listeria monocytogenes | Agar | 22.87 ± 0.27 | 30.33 ± 0.75 | 32.60 ± 0.20 | 27.87 ± 0.24 | 24.87 ± 0.71 | 26.33 ± 1.98 | 28.00 ± 2.01 | 31.53 ± 0.85 | 26.00 ± 0.31 | 32.13 ± 0.97 | 25.07 ± 0.24 |
Poloxamer | 18.27 ± 0.66 | 16.67 ± 0.90 | 21.27 ± 0.37 | 13.07 ± 1.05 | 11.27 ± 0.77 | 15.60 ± 0.31 | 13.93 ± 0.13 | 20.13 ± 0.33 | 13.40 ± 0.31 | 13.00 ± 6.51 | 11.80 ± 1.11 | |
Micrococcus sp | Agar | NM | NM | NM | NM | NM | NM | NM | NM | NM | NM | NM |
Poloxamer | 34.40 ± 0.31 | 33.80 ± 0.20 | 34.33 ± 0.18 | 17.27 ± 0.68 | 22.80 ± 0.50 | 21.40 ± 0.20 | 22.80 ± 0.12 | 33.27 ± 0.77 | 16.60 ± 0.12 | 28.13 ± 0.13 | 24.33 ± 0.13 | |
Nocardia asteroides | Agar | 31.40 ± 0.90 | 14.03 ± 1.32 | 16.87 ± 0.70 | 37.33 ± 0.41 | 13.13 ± 0.33 | 14.27 ± 0.37 | 14.73 ± 0.13 | 35.13 ± 0.59 | 38.40 ± 0.61 | 21.87 ± 0.18 | 8.33 ± 0.44 |
Poloxamer | 23.60 ± 0.31 | 11.47 ± 0.07 | 12.40 ± 0.20 | 25.60 ± 0.12 | 13.33 ± 0.68 | 8.93 ± 0.13 | 10.33 ± 0.13 | 27.53 ± 0.18 | 25.07 ± 0.13 | 19.47 ± 0.07 | 0.00 ± 0.00 | |
Staphylococcus aureus | Agar | 23.73 ± 0.18 | 18.47 ± 0.55 | 20.73 ± 0.18 | 27.13 ± 0.18 | 30.40 ± 0.95 | 27.13 ± 1.49 | 27.07 ± 1.11 | 33.00 ± 0.64 | 27.13 ± 0.07 | 25.67 ± 0.24 | 14.00 ± 0.76 |
Poloxamer | 17.73 ± 0.07 | 13.60 ± 0.31 | 14.07 ± 0.13 | 18.60 ± 0.20 | 14.93 ± 0.37 | 15.13 ± 0.59 | 14.73 ± 0.18 | 23.73 ± 2.03 | 18.40 ± 0.53 | 18.80 ± 2.62 | 5.53 ± 2.78 | |
Staphylococcus aureus NCIMB 12702 | Agar | 25.87 ± 0.07 | 24.80 ± 0.12 | 28.40 ± 0.12 | 22.60 ± 0.23 | 27.47 ± 0.27 | 21.87 ± 0.07 | 21.60 ± 0.12 | 32.27 ± 0.18 | 26.60 ± 0.20 | 36.47 ± 0.24 | 31.00 ± 0.00 |
Poloxamer | 22.33 ± 0.07 | 22.73 ± 0.07 | 17.07 ± 6.73 | 19.20 ± 0.00 | 16.53 ± 0.07 | 15.47 ± 0.24 | 15.53 ± 0.18 | 29.87 ± 0.07 | 19.60 ± 0.12 | 25.73 ± 0.07 | 20.27 ± 0.27 | |
Staphylococcus citreus | Agar | NM | NM | NM | NM | NM | NM | NM | NM | NM | NM | NM |
Poloxamer | 24.80 ± 0.00 | 23.80 ± 0.12 | 23.73 ± 0.79 | 17.80 ± 0.35 | 18.40 ± 0.12 | 19.93 ± 0.33 | 21.07 ± 0.07 | 30.80 ± 0.12 | 18.00 ± 0.12 | 26.93 ± 0.13 | 18.60 ± 0.00 | |
Staphylococcus epidermis | Agar | 33.07 ± 1.39 | 34.20 ± 0.53 | 35.27 ± 0.07 | 30.60 ± 0.70 | 30.80 ± 0.23 | 30.47 ± 1.17 | 34.00 ± 0.00 | 39.47 ± 0.27 | 30.60 ± 0.31 | 36.20 ± 0.92 | 33.67 ± 0.66 |
Poloxamer | 24.53 ± 0.13 | 24.93 ± 0.07 | 25.53 ± 0.07 | 19.93 ± 0.18 | 15.60 ± 0.83 | 15.47 ± 0.33 | 16.07 ± 0.18 | 28.53 ± 0.68 | 21.67 ± 0.35 | 25.13 ± 0.77 | 19.67 ± 0.35 | |
Staphylococcus hominis | Agar | NM | NM | NM | NM | NM | NM | NM | NM | NM | NM | NNM |
Poloxamer | 27.27 ± 0.29 | 26.87 ± 0.53 | 27.40 ± 0.20 | 16.33 ± 0.77 | 10.87 ± 0.33 | 18.53 ± 0.37 | 20.23 ± 0.15 | 30.87 ± 0.07 | 17.53 ± 0.13 | 26.80 ± 0.81 | 21.53 ± 0.47 | |
Staphylococcus hyicus | Agar | 34.47 ± 0.53 | 37.20 ± 0.12 | 38.60 ± 0.40 | 30.93 ± 0.13 | 28.33 ± 0.57 | 27.27 ± 0.07 | 28.60 ± 0.61 | 41.87 ± 0.13 | 29.00 ± 0.20 | 37.60 ± 0.00 | 38.00 ± 0.40 |
Poloxamer | 25.73 ± 0.07 | 25.80 ± 0.35 | 26.73 ± 0.24 | 21.67 ± 0.18 | 16.93 ± 0.07 | 14.40 ± 0.20 | 15.93 ± 0.07 | 31.60 ± 0.20 | 20.67 ± 0.13 | 27.00 ± 0.20 | 23.47 ± 0.13 | |
Staphylococcus intermedius | Agar | 33.00 ± 0.12 | 25.87 ± 0.07 | 25.33 ± 0.47 | 35.00 ± 0.40 | 28.00 ± 0.20 | 30.20 ± 0.42 | 27.40 ± 0.12 | 40.13 ± 0.41 | 32.20 ± 0.46 | 35.13 ± 0.41 | 9.13 ± 0.07 |