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Table 2 Mean [± standard error] zones of clearance (mm) around all the antibiotics for Gram positive bacteria [NM – Not measured

From: Evaluating antibiotics for use in medicine using a poloxamer biofilm model

 

ANTIBIOTIC

BACTERIA

Test Method [mm]

Amoxycillin/Clavulanic acid

Ampicillin/Sulbactam

Ampicillin/Sulbactam

Ciprofloxacin

Clindamycin

Erythromycin

Erythromycin

Imipenem

Levofloxacin

Meropenem

Penicillin G

  

30 μg

20 μg

30 μg

5 μg

10 μg

15 μg

30 μg

10 μg

5 μg

10 μg

5 IU

Bacillus cereus

Agar

13.87 ± 0.24

13.20 ± 0.00

14.93 ± 0.24

25.47 ± 0.07

25.73 ± 0.18

28.80 ± 0.23

30.07 ± 0.13

33.00 ± 0.64

24.87 ± 0.18

31.27 ± 0.68

7.07 ± 0.07

 

Poloxamer

11.60 ± 0.00

11.80 ± 0.00

12.33 ± 0.13

17.13 ± 0.33

15.40 ± 0.23

16.73 ± 0.18

18.13 ± 0.07

22.40 ± 1.11

18.00 ± 0.12

22.33 ± 0.18

0.00 ± 0.00

Bacillus licheniformis

Agar

25.87 ± 0.24

23.47 ± 0.66

25.73 ± 0.13

34.67 ± 0.84

0.00 ± 0.00

30.80 ± 0.20

31.27 ± 0.55

39.27 ± 0.18

33.33 ± 0.18

41.53 ± 0.07

0.00 ± 0.00

 

Poloxamer

18.13 ± 0.13

17.40 ± 0.00

18.20 ± 0.20

22.70 ± 0.32

8.73 ± 0.13

16.33 ± 0.07

17.53 ± 0.07

27.40 ± 0.12

21.60 ± 0.23

23.47 ± 0.18

9.40 ± 0.20

Corynebacterium pseudotuberculosis

Agar

NM

NM

NM

NM

NM

NM

NM

NM

NM

NM

NM

 

Poloxamer

29.87 ± 0.13

27.33 ± 0.29

28.93 ± 0.47

31.53 ± 0.59

18.13 ± 0.18

25.87 ± 0.48

26.40 ± 0.64

35.33 ± 0.55

28.93 ± 1.23

30.13 ± 0.64

22.73 ± 0.29

Corynebacterium renale

Agar

NM

NM

NM

NM

NM

NM

NM

NM

NM

NM

NM

 

Poloxamer

32.47 ± 0.75

31.20 ± 0.23

31.00 ± 0.69

20.20 ± 0.12

19.07 ± 0.35

22.33 ± 0.18

24.00 ± 0.00

35.53 ± 0.13

19.40 ± 0.00

30.47 ± 0.27

25.40 ± 0.31

Enterococcus faecalis

Agar

31.67 ± 0.13

27.07 ± 0.13

29.20 ± 0.00

20.87 ± 0.07

12.00 ± 0.20

24.53 ± 0.18

25.53 ± 0.24

29.67 ± 0.47

22.13 ± 0.24

23.27 ± 0.27

20.13 ± 0.64

 

Poloxamer

16.80 ± 0.20

17.13 ± 0.24

18.60 ± 0.12

13.53 ± 0.18

8.20 ± 0.12

10.00 ± 0.20

10.47 ± 0.18

19.27 ± 0.18

13.13 ± 0.18

15.73 ± 0.13

12.27 ± 0.13

Listeria ivanovii

Agar

11.07 ± 0.27

7.20 ± 0.00

7.73 ± 0.07

36.07 ± 0.29

7.27 ± 0.07

9.87 ± 0.07

11.80 ± 0.83

36.60 ± 0.69

28.27 ± 0.47

25.40 ± 0.40

7.40 ± 0.12

 

Poloxamer

8.67 ± 0.13

7.20 ± 0.00

7.20 ± 0.00

22.07 ± 0.41

7.20 ± 0.00

8.73 ± 0.07

8.67 ± 0.07

22.67 ± 0.07

20.73 ± 0.13

19.47 ± 0.41

0.00 ± 0.00

Listeria monocytogenes

Agar

22.87 ± 0.27

30.33 ± 0.75

32.60 ± 0.20

27.87 ± 0.24

24.87 ± 0.71

26.33 ± 1.98

28.00 ± 2.01

31.53 ± 0.85

26.00 ± 0.31

32.13 ± 0.97

25.07 ± 0.24

 

Poloxamer

18.27 ± 0.66

16.67 ± 0.90

21.27 ± 0.37

13.07 ± 1.05

11.27 ± 0.77

15.60 ± 0.31

13.93 ± 0.13

20.13 ± 0.33

13.40 ± 0.31

13.00 ± 6.51

11.80 ± 1.11

Micrococcus sp

Agar

NM

NM

NM

NM

NM

NM

NM

NM

NM

NM

NM

 

Poloxamer

34.40 ± 0.31

33.80 ± 0.20

34.33 ± 0.18

17.27 ± 0.68

22.80 ± 0.50

21.40 ± 0.20

22.80 ± 0.12

33.27 ± 0.77

16.60 ± 0.12

28.13 ± 0.13

24.33 ± 0.13

Nocardia asteroides

Agar

31.40 ± 0.90

14.03 ± 1.32

16.87 ± 0.70

37.33 ± 0.41

13.13 ± 0.33

14.27 ± 0.37

14.73 ± 0.13

35.13 ± 0.59

38.40 ± 0.61

21.87 ± 0.18

8.33 ± 0.44

 

Poloxamer

23.60 ± 0.31

11.47 ± 0.07

12.40 ± 0.20

25.60 ± 0.12

13.33 ± 0.68

8.93 ± 0.13

10.33 ± 0.13

27.53 ± 0.18

25.07 ± 0.13

19.47 ± 0.07

0.00 ± 0.00

Staphylococcus aureus

Agar

23.73 ± 0.18

18.47 ± 0.55

20.73 ± 0.18

27.13 ± 0.18

30.40 ± 0.95

27.13 ± 1.49

27.07 ± 1.11

33.00 ± 0.64

27.13 ± 0.07

25.67 ± 0.24

14.00 ± 0.76

 

Poloxamer

17.73 ± 0.07

13.60 ± 0.31

14.07 ± 0.13

18.60 ± 0.20

14.93 ± 0.37

15.13 ± 0.59

14.73 ± 0.18

23.73 ± 2.03

18.40 ± 0.53

18.80 ± 2.62

5.53 ± 2.78

Staphylococcus aureus NCIMB 12702

Agar

25.87 ± 0.07

24.80 ± 0.12

28.40 ± 0.12

22.60 ± 0.23

27.47 ± 0.27

21.87 ± 0.07

21.60 ± 0.12

32.27 ± 0.18

26.60 ± 0.20

36.47 ± 0.24

31.00 ± 0.00

 

Poloxamer

22.33 ± 0.07

22.73 ± 0.07

17.07 ± 6.73

19.20 ± 0.00

16.53 ± 0.07

15.47 ± 0.24

15.53 ± 0.18

29.87 ± 0.07

19.60 ± 0.12

25.73 ± 0.07

20.27 ± 0.27

Staphylococcus citreus

Agar

NM

NM

NM

NM

NM

NM

NM

NM

NM

NM

NM

 

Poloxamer

24.80 ± 0.00

23.80 ± 0.12

23.73 ± 0.79

17.80 ± 0.35

18.40 ± 0.12

19.93 ± 0.33

21.07 ± 0.07

30.80 ± 0.12

18.00 ± 0.12

26.93 ± 0.13

18.60 ± 0.00

Staphylococcus epidermis

Agar

33.07 ± 1.39

34.20 ± 0.53

35.27 ± 0.07

30.60 ± 0.70

30.80 ± 0.23

30.47 ± 1.17

34.00 ± 0.00

39.47 ± 0.27

30.60 ± 0.31

36.20 ± 0.92

33.67 ± 0.66

 

Poloxamer

24.53 ± 0.13

24.93 ± 0.07

25.53 ± 0.07

19.93 ± 0.18

15.60 ± 0.83

15.47 ± 0.33

16.07 ± 0.18

28.53 ± 0.68

21.67 ± 0.35

25.13 ± 0.77

19.67 ± 0.35

Staphylococcus hominis

Agar

NM

NM

NM

NM

NM

NM

NM

NM

NM

NM

NNM

 

Poloxamer

27.27 ± 0.29

26.87 ± 0.53

27.40 ± 0.20

16.33 ± 0.77

10.87 ± 0.33

18.53 ± 0.37

20.23 ± 0.15

30.87 ± 0.07

17.53 ± 0.13

26.80 ± 0.81

21.53 ± 0.47

Staphylococcus hyicus

Agar

34.47 ± 0.53

37.20 ± 0.12

38.60 ± 0.40

30.93 ± 0.13

28.33 ± 0.57

27.27 ± 0.07

28.60 ± 0.61

41.87 ± 0.13

29.00 ± 0.20

37.60 ± 0.00

38.00 ± 0.40

 

Poloxamer

25.73 ± 0.07

25.80 ± 0.35

26.73 ± 0.24

21.67 ± 0.18

16.93 ± 0.07

14.40 ± 0.20

15.93 ± 0.07

31.60 ± 0.20

20.67 ± 0.13

27.00 ± 0.20

23.47 ± 0.13

Staphylococcus intermedius

Agar

33.00 ± 0.12

25.87 ± 0.07

25.33 ± 0.47

35.00 ± 0.40

28.00 ± 0.20

30.20 ± 0.42

27.40 ± 0.12

40.13 ± 0.41

32.20 ± 0.46

35.13 ± 0.41

9.13 ± 0.07