Table 3 Cumulative fraction of response for various drug regimens against P. aeruginosa MICs collected from the Merck ICU Surveillance Study (ISS) Program, in four time intervals.
Antimicrobial agent: | CFRa (%) | ||||
|---|---|---|---|---|---|
Time interval: | 1993–1995b | 1996–1998 | 1999–2001 | 2002–2004 | p-value |
Imipenem 500 mg q6h | 81.6 | 81.9 | 79.5 | 78.5 | <.0001 |
Imipenem 1 g q8h | 81.9 | 82.0 | 79.8 | 78.7 | <.0001 |
Ceftriaxone 1 g q24h | 1.4 | 1.4 | 1.4 | 1.3 | .6217 |
Ceftriaxone 2 g q24h | 3.2 | 3.2 | 3.1 | 2.8 | .2903 |
Cefepime 1 g q12h | - | 69.9 | 68.3 | 67.2 | .0035 |
Cefepime 2 g q12h | - | 83.5 | 82.9 | 81.8 | .0240 |
Cefepime 2 g q8h | - | 92.2 | 92.7 | 91.2 | .0842 |
Pip-Tazo 3.375 g q6h | - | 75.9 | 74.0 | 73.3 | .0024 |
Pip-Tazo 4.5 g q8h | - | 70.8 | 69.0 | 68.4 | .0095 |
Pip-Tazo 4.5 g q6h | - | 79.6 | 77.5 | 76.7 | .0004 |