Table 2 Cumulative fraction of response for various drug regimens against MICs collected from the Merck ICU Surveillance Study (ISS) Program, in four time intervals.
Antimicrobial agent: | CFRa (%) | ||||
|---|---|---|---|---|---|
Time interval: | 1993–1995b | 1996–1998 | 1999–2001 | 2002–2004 | p-value |
Imipenem 500 mg q6h | 87.0 | 87.7 | 88.2 | 90.6 | <.0001 |
Imipenem 1 g q8h | 86.8 | 87.3 | 87.9 | 90.2 | <.0001 |
Ceftriaxone 1 g q24h | 32.5 | 30.9 | 32.3 | 31.5 | .6128 |
Ceftriaxone 2 g q24h | 51.6 | 49.2 | 51.2 | 50.0 | .3726 |
Cefepime 1 g q12h | - | 80.6 | 80.4 | 78.6 | .0118 |
Cefepime 2 g q12h | - | 86.8 | 87.5 | 84.8 | .0027 |
Cefepime 2 g q8h | - | 91.8 | 93.5 | 89.9 | .0006 |
Pip-Tazo 3.375 g q6h | - | 76.6 | 77.3 | 75.1 | .0667 |
Pip-Tazo 4.5 g q8h | - | 72.1 | 72.9 | 70.9 | .1569 |
Pip-Tazo 4.5 g q6h | - | 79.4 | 79.9 | 77.5 | .0175 |