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Table 1 Antimicrobial activity of naphthoquinones against Staphylococcus species.

From: Tabebuia avellanedae naphthoquinones: activity against methicillin-resistant staphylococcal strains, cytotoxic activity and in vivo dermal irritability analysis

Compounds

S. aureus ATCC 29213 (MSSA)

S. aureus ATCC 33591 (MRSA)

S. epidermidis MRSE 228

S. haemolyticus MRSH 225

 

MIC (μg/mL)

MBC (μg/mL)

MIC (μg/mL)

MBC (μg/mL)

MIC (μg/mL)

MBC (μg/mL)

MIC (μg/mL)

MBC (μg/mL)

Ia

256

>512

256

>512

ND

ND

ND

ND

II

64

>512

64

>512

128

>512

128

>512

III

8

>512

8

>512

8

>512

8

>512

IV

8

>512

8

>512

4

>512

8

>512

  1. ND → not determined. Compounds: I) Lapachol; II) α-lapachone; III) β-lapachone; IV) (±) 3-hydroxy-β-N-lapachone. MIC = Minimal Inhibitory Concentration MBC = Minimal Bactericidal Concentration