Skip to main content

Table 1 Antimicrobial activity of naphthoquinones against Staphylococcus species.

From: Tabebuia avellanedae naphthoquinones: activity against methicillin-resistant staphylococcal strains, cytotoxic activity and in vivo dermal irritability analysis

Compounds S. aureus ATCC 29213 (MSSA) S. aureus ATCC 33591 (MRSA) S. epidermidis MRSE 228 S. haemolyticus MRSH 225
  MIC (μg/mL) MBC (μg/mL) MIC (μg/mL) MBC (μg/mL) MIC (μg/mL) MBC (μg/mL) MIC (μg/mL) MBC (μg/mL)
Ia 256 >512 256 >512 ND ND ND ND
II 64 >512 64 >512 128 >512 128 >512
III 8 >512 8 >512 8 >512 8 >512
IV 8 >512 8 >512 4 >512 8 >512
  1. ND → not determined. Compounds: I) Lapachol; II) α-lapachone; III) β-lapachone; IV) (±) 3-hydroxy-β-N-lapachone. MIC = Minimal Inhibitory Concentration MBC = Minimal Bactericidal Concentration