Table 3 Rifampicin and rifabutin MICs of selected first generation in vitro mutants.
rpoB Mutation | Number of Isolates | RIF MIC μg/ml | Number of Isolates | RFB MIC μg/ml |
|---|---|---|---|---|
Wild | 2 | <4 | 2 | <0.8 |
Q513L | 1 | 256 | 1 | >128 |
S522L | 1 | 32 | 1 | <0.8 |
H526Y | 3 | 256 | 1 | >128 |
1 | 128 | 2 | 128 | |
1 | 64 | |||
H526D | 3 | 256 | 1 | >128 |
1 | 128 | 3 | 128 | |
H526R | 1 | 512 | 5 | 128 |
3 | 256 | |||
1 | 128 | |||
H526P | 1 | 256 | 1 | >128 |
S531L | 4 | 256 | 1 | >128 |
2 | 128 | |||
1 | 64 | |||
S531W | 1 | 256 | 1 | 128 |