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Table 2 AASLD Recommendations for Treatment of Chronic Hepatitis C

From: Natural history and treatment of hepatitis B virus and hepatitis C virus coinfection

Therapy Widely Accepted Therapy Contraindicated Treatment Recommendations
• Detectable HCV RNA
• 18 years of age or older
• Elevated ALT
• Liver biopsy showing chronic hepatitis with significant fibrosis
• Compensated liver disease (total serum bilirubin <1.5 g/dL; INR <1.5; albumin >3.4 g/dL; platelet count >75,000 k/mm3; and no evidence of hepatic encephalopathy or ascites)
• Acceptable hematological and biochemical indices (hemoglobin >13 g/dL for men and >12 g/dL for women; neutrophil count >1.5 k/mm3; creatinine <1.5 mg/dL)
• Not treated previously for HCV infection
• History of depression but well controlled
• Patient willing to be treated and to conform to treatment requirements
• Major, uncontrolled depression
• Renal, heart, or lung transplant recipient
• Autoimmune hepatitis or other condition known to be exacerbated by interferon and ribavirin
• Untreated hyperthyroidism
• Pregnant or unwilling/unable to comply with adequate contraception
• Severe concurrent disease such as severe hypertension, heart failure, significant coronary artery disease, poorly controlled diabetes, obstructive pulmonary disease
• Under 3 years of age
• Known hypersensitivity to drugs used to treat HCV
Genotype 1 HCV infection:
• Peginterferon plus ribavirin (1000–1200 mg daily) for 48 weeks
• Treatment may be discontinued in patients who do not achieve an EVR at 12 weeks
• In patients who have negative HCV RNA at 48 weeks, retest HCV RNA at 72 weeks to confirm SVR
Genotype 2 or Genotype 3 infection:
• Peginterferon plus ribavirin (800 mg daily) for 24 weeks
• In patients who have negative HCV RNA at 24 weeks, retest HCV RNA at 48 weeks to confirm SVR
  1. Abbreviations: INR: international normalized ratio; EVR: early virologic response; SVR: sustained virologic response. Source: Strader DB, Wright T, Thomas DL, Seeff LB. Diagnosis, management, and treatment of hepatitis C. Hepatology 2004;39:1147-71.