Table 2 S. aureus, Coagulase-negative staphylococci, E. faecalis, and E. faecium isolated from ICU patients during 2000–2002
United States | Canada | Italy | Germany | Francea | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Organism | Agent | Total n | %S | %R | Total n | %S | %R | Total n | %S | %R | Total n | %S | %R | Total n | %S | %R |
Staphylococcus aureus | Ampicillin | 19,703 | 6.7 | 93.3 | 3,792 | 12.6 | 87.4 | 1,665 | 5.6 | 94.4 | 2,867 | 16.2 | 83.8 | 15 | 6.7 | 93.3 |
Cefepime | 1,260 | 52.9 | 46.9 | NTb | NT | NT | 304 | 15.8 | 84.2 | 483 | 80.5 | 17.0 | <10 | NAc> | NA | |
Cefotaxime | 6,898 | 50.2 | 49.7 | 220 | 55.5 | 44.5 | 671 | 36.4 | 63.6 | 729 | 92.0 | 8.0 | 490 | 63.9 | 36.1 | |
Ceftriaxone | 5,914 | 45.6 | 54.3 | 153 | 69.3 | 30.7 | 1,048 | 28.1 | 71.8 | 220 | 88.6 | 11.4 | 23 | 73.9 | 26.1 | |
Ciprofloxacin | 24,350 | 47.4 | 51.0 | 5,958 | 74.5 | 24.1 | 4,600 | 39.7 | 58.6 | 5,243 | 73.4 | 26.1 | 316 | 57.0 | 40.5 | |
Gentamicin | 35,034 | 85.6 | 13.7 | 6,641 | 89.4 | 10.3 | 5,531 | 40.9 | 58.0 | 5,735 | 90.0 | 9.7 | 10,100 | 90.4 | 9.4 | |
Oxacillin | 44,939 | 47.7 | 52.3 | 10,105 | 80.3 | 19.7 | 6,147 | 40.6 | 59.4 | 6,475 | 79.0 | 21.0 | 10,512 | 59.4 | 40.6 | |
Teicoplanin | NT | NT | NT | NT | NT | NT | 5,868 | 100 | 0 | 4,632 | 99.8 | 0.2 | 8,232 | 100 | 0 | |
Vancomycin | 43,245 | 100 | 0 | 7,882 | 100 | 0 | 5,937 | 100 | 0 | 5,276 | 100 | 0 | 9,453 | 100 | 0 | |
Staphylococcus aureus | ||||||||||||||||
OSSA | Ampicillin | 9,047 | 14.5 | 85.5 | 3,055 | 15.7 | 84.3 | 741 | 12.6 | 87.4 | 2,414 | 19.3 | 80.7 | 10 | 0 | 100 |
Cefepime | 672 | 99.1 | 0.4 | NT | NT | NT | 49 | 98.0 | 2.0 | 387 | 99.5 | 0.3 | NT | NT | NT | |
Cefotaxime | 3,451 | 99.7 | 0.2 | 122 | 100 | 0 | 244 | 100 | 0 | 653 | 100 | 0 | 312 | 100 | 0 | |
Ceftriaxone | 2,707 | 99.5 | 0.2 | 106 | 100 | 0 | 295 | 99.0 | 0.3 | 194 | 100 | 0 | 16 | 100 | 0 | |
Ciprofloxacin | 11,827 | 91.2 | 6.5 | 4,692 | 93.5 | 4.8 | 1,902 | 91.4 | 4.9 | 4,171 | 91.4 | 8.0 | 188 | 90.4 | 6.4 | |
Gentamicin | 16,951 | 98.3 | 1.4 | 5,384 | 98.1 | 1.8 | 2,223 | 95.1 | 4.5 | 4,527 | 98.4 | 1.5 | 5,958 | 99.4 | 0.5 | |
Oxacillin | 21,416 | 100 | 0 | 8,110 | 100 | 0 | 2,495 | 100 | 0 | 5,115 | 100 | 0 | 6,244 | 100 | 0 | |
Teicoplanin | NT | NT | NT | NT | NT | NT | 2,402 | 100 | 0 | 3,593 | 99.9 | 0.1 | 5,018 | 100 | 0 | |
Vancomycin | 20,110 | 100 | 0 | 6,046 | 100 | 0 | 2,430 | 100 | 0 | 4,002 | 100 | 0 | 5,580 | 100 | 0 | |
Staphylococcus aureus | ||||||||||||||||
ORSA | Ampicillin | 10,656 | 0 | 100 | 737 | 0 | 100 | 924 | 0 | 100 | 453 | 0 | 100 | <10 | NA | NA |
Cefepime | 588 | 0 | 100 | NT | NT | NT | 255 | 0 | 100 | 96 | 4.2 | 84.4 | <10 | NA | NA | |
Cefotaxime | 3,447 | 0.6 | 99.3 | 98 | 0 | 100 | 427 | 0 | 100 | 76 | 23.7 | 76.3 | 178 | 0.6 | 99.4 | |
Ceftriaxone | 3,207 | 0 | 100 | 47 | 0 | 100 | 753 | 0.3 | 99.7 | 26 | 3.8 | 96.2 | <10 | NA | NA | |
Ciprofloxacin | 12,523 | 6.1 | 93.1 | 1,266 | 3.9 | 95.5 | 2,698 | 3.3 | 96.4 | 1,072 | 3.3 | 96.6 | 128 | 7.8 | 90.6 | |
Gentamicin | 18,083 | 73.7 | 25.2 | 1,257 | 52.0 | 46.8 | 3,308 | 4.5 | 94.0 | 1,208 | 58.7 | 40.5 | 4,142 | 77.5 | 22.2 | |
Oxacillin | 23,523 | 0 | 100 | 1,995 | 0.2 | 99.8 | 3,652 | 0 | 100 | 1,360 | 0 | 100 | 4,268 | 0 | 100 | |
Teicoplanin | NT | NT | NT | NT | NT | NT | 3,466 | 100 | 0 | 1,039 | 99.7 | 0.3 | 3,214 | 100 | 0 | |
Vancomycin | 23,135 | 100 | 0 | 1,836 | 100 | 0 | 3,507 | 100 | 0 | 1,274 | 100 | 0 | 3,873 | 100 | 0 | |
Staphylcoccus species, coagulase-negative | ||||||||||||||||
Ampicillin | 16,288 | 5.7 | 94.3 | 3,533 | 6.3 | 93.7 | 2,142 | 10.6 | 89.4 | 4,075 | 8.1 | 91.9 | <10 | NA | NA | |
Cefepime | 991 | 11.8 | 88.1 | <10 | NA | NA | 116 | 0 | 100 | 625 | 11.0 | 73.1 | <10 | NA | NA | |
Cefotaxime | 5,538 | 17.7 | 82.3 | 240 | 17.9 | 82.1 | 335 | 16.7 | 83.3 | 625 | 37.4 | 62.4 | 174 | 28.7 | 69.0 | |
Ceftriaxone | 3,471 | 14.8 | 84.8 | 116 | 22.4 | 77.6 | 512 | 11.7 | 88.3 | 412 | 25.0 | 74.8 | <10 | NA | NA | |
Ciprofloxacin | 18,829 | 40.2 | 58.3 | 5,366 | 44.4 | 54.7 | 5,102 | 42.7 | 54.0 | 6,197 | 29.5 | 67.6 | 198 | 44.4 | 53.0 | |
Gentamicin | 27,248 | 51.5 | 38.1 | 5,571 | 40.6 | 47.3 | 5,241 | 33.8 | 60.7 | 6,848 | 41.5 | 51.7 | 9,422 | 46.8 | 51.5 | |
Oxacillin | 35,135 | 15.8 | 84.2 | 9,172 | 20.6 | 79.4 | 5,961 | 15.2 | 84.8 | 7,442 | 18.6 | 81.4 | 9,884 | 30.1 | 69.9 | |
Teicoplanin | NT | NT | NT | NT | NT | NT | 5,797 | 93.7 | 2.4 | 5,096 | 95.6 | 0.7 | 7,670 | 84.6 | 3.1 | |
Vancomycin | 34,424 | 100 | 0 | 8,239 | 100 | 0 | 5,937 | 100 | 0 | 6,953 | 100 | 0 | 8,300 | 100 | 0 | |
Staphylcoccus species, coagulase-negative | ||||||||||||||||
Oxacillin susceptible | Ampicillin | 2,582 | 35.7 | 64.3 | 638 | 34.6 | 65.4 | 437 | 51.7 | 48.3 | 824 | 39.6 | 60.4 | <10 | NA | NA |
Cefepime | 117 | 100 | 0 | NT | NT | NT | NT | NT | NT | <10 | NA | NA | NT | NT | NT | |
Cefotaxime | 978 | 99.5 | 0.2 | 42 | 100 | 0 | 56 | 100 | 0 | 128 | 100 | 0 | 54 | 92.6 | 0 | |
Ceftriaxone | 523 | 98.3 | 0.4 | 26 | 100 | 0 | 59 | 100 | 0 | 103 | 100 | 0 | <10 | NA | NA | |
Ciprofloxacin | 2,844 | 82.4 | 16.6 | 988 | 91.8 | 7.6 | 779 | 87.7 | 10.1 | 1,103 | 89.5 | 9.2 | 78 | 83.3 | 14.1 | |
Gentamicin | 4,424 | 93.5 | 4.2 | 1,068 | 91.9 | 5.3 | 698 | 94.3 | 5.3 | 1,263 | 96.5 | 2.7 | 2,822 | 93.9 | 5.4 | |
Oxacillin | 5,565 | 100 | 0 | 1,886 | 99.9 | 0.1 | 904 | 100 | 0 | 1,383 | 100 | 0 | 2,980 | 100 | 0 | |
Teicoplanin | NT | NT | NT | NT | NT | NT | 890 | 99.1 | 0.3 | 691 | 98.4 | 0.3 | 2,454 | 95.8 | 0.2 | |
Vancomycin | 5,240 | 100 | 0 | 1,587 | 100 | 0 | 897 | 100 | 0 | 981 | 100 | 0 | 2,467 | 100 | 0 | |
Staphylcoccus species, coagulase-negative | ||||||||||||||||
Oxacillin resistant | Ampicillin | 13,706 | 0.1 | 99.9 | 2,895 | 0 | 100 | 1,705 | 0 | 100 | 3,251 | 0.2 | 99.8 | <10 | NA | NA |
Cefepime | 874 | 0 | 99.9 | <10 | NA | NA | 116 | 0 | 100 | 624 | 10.9 | 73.2 | <10 | NA | NA | |
Cefotaxime | 4,560 | 0.1 | 99.9 | 198 | 0.5 | 99.5 | 279 | 0 | 100 | 497 | 21.3 | 78.5 | 120 | 0 | 100 | |
Ceftriaxone | 2,948 | 0 | 99.8 | 90 | 0 | 100 | 453 | 0.2 | 99.8 | 309 | 0.0 | 99.7 | <10 | NA | NA | |
Ciprofloxacin | 15,985 | 32.7 | 65.8 | 4,378 | 33.7 | 65.3 | 4,323 | 34.7 | 61.9 | 5,094 | 16.5 | 80.2 | 120 | 19.2 | 78.3 | |
Gentamicin | 22,824 | 43.3 | 44.7 | 4,503 | 28.5 | 57.3 | 4,543 | 24.5 | 69.2 | 5,585 | 29.1 | 62.8 | 6,600 | 26.6 | 71.3 | |
Oxacillin | 29,570 | 0 | 100 | 7,286 | 0 | 100 | 5,057 | 0 | 100 | 6,059 | 0 | 100 | 6,904 | 0 | 100 | |
Teicoplanin | NT | NT | NT | NT | NT | NT | 4,907 | 92.7 | 2.8 | 4,405 | 95.1 | 0.8 | 5,216 | 79.3 | 4.5 | |
Vancomycin | 29,184 | 100 | 0 | 6,652 | 100 | 0 | 5,040 | 100 | 0 | 5,972 | 100 | 0 | 5,833 | 100 | 0 | |
Enterococcus faecalis | ||||||||||||||||
Ampicillin | 7,865 | 98.8 | 1.2 | 1,000 | 99.4 | 0.6 | 1,289 | 95.3 | 4.7 | 1,902 | 99.6 | 0.4 | 1,183 | 99.5 | 0.2 | |
Ciprofloxacin | 3,311 | 56.9 | 38.7 | 625 | 45.3 | 50.4 | 1,159 | 64.0 | 31.1 | 2,012 | 39.7 | 39.5 | 559 | 78.5 | 17.0 | |
Gentamicin (HL Testing) | 5,503 | 65.1 | 34.8 | 706 | 63.0 | 36.8 | 1,156 | 62.9 | 37.1 | 965 | 64.8 | 35.2 | 1,563 | 63.6 | 13.4 | |
Teicoplanin | NT | NT | NT | <10 | NA | NA | 1,248 | 97.1 | 2.4 | 1,294 | 99.7 | 0.2 | 1,747 | 99.9 | 0.1 | |
Vancomycin | 7,656 | 95.1 | 4.5 | 1,005 | 98.3 | 0.9 | 1,303 | 96.7 | 2.8 | 1,636 | 99.4 | 0.3 | 1,811 | 99.7 | 0.2 | |
Enterococcus faecium | ||||||||||||||||
Ampicillin | 3,896 | 9.7 | 90.3 | 383 | 17.2 | 82.8 | 260 | 21.5 | 78.5 | 481 | 12.3 | 87.7 | 151 | 41.7 | 49.7 | |
Ciprofloxacin | 1,846 | 5.3 | 92.5 | 221 | 10.9 | 85.5 | 234 | 10.3 | 77.4 | 591 | 6.9 | 73.9 | 66 | 21.2 | 39.4 | |
Gentamicin (HL Testing) | 2,512 | 57.5 | 42.5 | 291 | 59.5 | 40.5 | 223 | 67.7 | 32.3 | 349 | 60.2 | 39.8 | 263 | 65.4 | 12.2 | |
Teicoplanin | 23 | 8.7 | 87.0 | <10 | NA | NA | 234 | 86.3 | 13.7 | 517 | 97.9 | 2.1 | 266 | 99.6 | 0.4 | |
Vancomycin | 4,066 | 23.2 | 76.3 | 415 | 85.1 | 14.5 | 264 | 75.4 | 24.2 | 628 | 93.9 | 4.8 | 247 | 98.4 | 0.8 | |