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Table 1 Serotype distribution of S. pneumoniae isolates from children with acute otitis media by age group and potential vaccine coverige: 1994-2011

From: Microbiological characterization of Streptococcus pneumoniae and non-typeable Haemophilus influenzae isolates as primary causes of acute otitis media in Bulgarian children before the introduction of conjugate vaccines

Serotype

No. of isolates per age group

Total no. (%) of particular serotype

 

≤ 2 y

> 2–5 y

≤ 5 y

> 5 y - 14 y

 

PCV7 serotypes

19 F

17

7

24

2

26 (20.3)

6 B

8

9

17

3

20 (15.6)

14

10

-

10

1

11 (8.6)

9 V

5

3

8

3

11 (8.6)

23 F

5

4

9

1

10 (7.8)

18 C

1

1

2

1

3 (2.3)

Total no.

46

24

70

11

81 (63.3)

Other vaccine serotypes

19 A

9

4

13

1

14 (10.9)

3

2

3

5

1

6 (4.7)

6 A

1

2

3

1

4 (3.1)

7 F

1

1

2

-

2 (1.6)

1

-

1

1

1

2 (1.6)

Total no.

13

11

24

4

28 (21.9)

Non-vaccine serotypes

15 B

2

3

5

-

5 (3.9)

23 A

2

1

3

-

3 (2.3)

11a

-

2

2

-

2 (1.6)

13,28b

-

1

1

1

2 (1.6)

15 C

-

2

2

-

2 (1.6)

10a

1

1

2

-

2 (1.6)

16/36/37b

-

-

-

1

1 (0.8)

24/31/40b

-

1

1

-

1 (0.8)

NTc

-

-

-

1

1 (0.8)

Total no.

5

11

16

3

19 (14.8)

Overall no. (%)

64 (50.0)

46 (35.9)

110 (85.9)

18 (14.1)

128 (100.0)

Percentage coverage rate of pneumococcal conjugate vaccines

PCV7

71.9

52.2

63.6

61.1

63.3

PCV10

73.4

56.5

66.4

66.7

66.4

PCV13

92.2

76.1

85.5

83.3

85.2

  1. a The strains were determined to serogroup.
  2. b Expected to be serotypes/serogroups (Strains were positive only for one of the pooled sera).
  3. c Non-typeable strains with Pneumotest-kit sera.