Free radical scavenging capacity, anticandicidal effect of bioactive compounds from Sida Cordifolia L., in combination with nystatin and clotrimazole and their effect on specific immune response in rats

Table 6 Fractional inhibitory concentration (FIC) and FICI of combination of n-butanol fraction from Sida cordifolia L. with Clotrimazole

Microorganisms	FIC_a	FIC_b	FICI	Effect
*C. albicans* ATCC 9002	0.12	0.31	0.43	Synergistic
*C. albicans* ATCC 2091	0.12	0.21	0.33	Synergistic
*C. parapsilosis* ATCC 22019	0.10	0.25	0.35	Synergistic
*C. krusei* ATCC 6258	0.12	0.31	0.43	Synergistic
*C. tropicalis* ATCC 750	0.10	0.25	0.35	Synergistic

FIC_a = MICa alone /MIC of AC in combination; FIC_b = MICb of standard antifungal agent/MIC of the antifungal agent in combination and FICI= FIC_a + FIC_b.
a= alkaloid compounds; b= Clotrimazole.
The FICI was interpreted as follows: (1) a synergistic effect when FICI =0.5; (2) an additive or indifferent effect when FICI >0.5 and <3C;1; (3) an antagonistic effect when >1.

ISSN: 1476-0711