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Table 3 Susceptibility of WT and diclofenac reduced susceptibility (DcRS) mutants to NSAIDs

From: Alterations in the transcriptome and antibiotic susceptibility of Staphylococcus aureus grown in the presence of diclofenac

  

Drug gradient plates (mg/ml)a

  

Strain

Ace (0→9)

Asa (0→3.6)

Ben (0→14.4)

Dc (0→0.5)

Ibu (0→4)

Sal (0→8)

SH1000

51 ± 4.2b

24 ± 1.0

54 ± 3.2

13 ± 1.5

0

24 ± 2.1

SC-1

51 ± 3.5

25 ± 0.6

52 ± 3.2

35 ± 5.4*

28 ± 2.3*

27 ± 0.6

COL

35 ± 1.2

22 ± 0.6

39 ± 3.2

23 ± 5.8

12 ± 1.5

31 ± 1.2

SC-4

35 ± 0.6

21 ± 1.5

31 ± 1.5

35 ± 3.6*

21 ± 0*

30 ± 1.2

  1. a Gradient plate technique; drug gradients prepared for acetaminophen (Ace), acetyl salicylic acid (Asa), benzoate (Ben), diclofenac (Dc), ibuprophen (Ibu), and sodium salicylate (Sal); concentration gradient provided in parentheses.
  2. b Average growth into NSAID gradients and standard deviation provided in mm.
  3. * Denotes statistically significant difference between WT and DcRS by Student's t-test (P < 0.05).
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Annals of Clinical Microbiology and Antimicrobials

ISSN: 1476-0711

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