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Table 1 Minimum inhibitory concentration of WSP1267, fluconazole, itraconazole and amphotericin B against 54 Candida spp. clinical isolates.

From: Synthetic arylquinuclidine derivatives exhibit antifungal activity against Candida albicans, Candida tropicalis and Candida parapsilopsis

Drugs All species
(n = 54)
C. albicans
(n = 21)
C. parapsilosis
(n = 19)
C. tropicalis
(n = 14)
WSP1267     
Range 0.5-16 0.5-8 0.5-8 2-16
Geometric mean 2.54 2.2 2.46 3.32
MIC50 2 2 2 2
MIC90 8 8 4 8
Fluconazole     
Range <0.25 to >128a <0.25 to 2 <0.25 to 1 <0.25 to >128a
Geometric mean 0.58 0.48 0.61 0.65
MIC50 0.25 0.25 0.5 0.5
MIC90 1 1 1 4
Itraconazole     
Range <0.03 to >16b <0.03 to 0.5 <0.03 to 0.5 <0.03 to >16b
Geometric mean 0.05 0.09 0.05 0.05
MIC50 0.03 0.03 0.03 0.03
MIC90 0.06 0.12 0.03 0.03
Amphotericin B     
Range 0.007-0.5 0.007-0.25 0.007-0.25 0.007-0.5
Geometric mean 0.04 0.05 0.03 0.04
MIC50 0.03 0.03 0.03 0.06
MIC90 0.12 0.12 0.25 0.12
  1. (MIC values are expressed in μg/ml)
  2. a Resistant (two C. tropicalis) and trailing effect (nine C. albicans, four C. tropicalis, and three C. parapsilosis)
  3. b Resistant (three C. tropicalis, one C. albicans), susceptibility dependence-dose (three C. albicans, two C. tropicalis and one C. parapsilosis) and trailing effect (six C. albicans, four C. tropicalis and one C. parapsilosis).