Synthetic arylquinuclidine derivatives exhibit antifungal activity against Candida albicans, Candida tropicalis and Candida parapsilopsis

Table 1 Minimum inhibitory concentration of WSP1267, fluconazole, itraconazole and amphotericin B against 54 Candida spp. clinical isolates.

Drugs	All species (n = 54)	*C. albicans* (n = 21)	*C. parapsilosis* (n = 19)	*C. tropicalis* (n = 14)
WSP1267
Range	0.5-16	0.5-8	0.5-8	2-16
Geometric mean	2.54	2.2	2.46	3.32
MIC₅₀	2	2	2	2
MIC₉₀	8	8	4	8
Fluconazole
Range	<0.25 to >128^a	<0.25 to 2	<0.25 to 1	<0.25 to >128^a
Geometric mean	0.58	0.48	0.61	0.65
MIC₅₀	0.25	0.25	0.5	0.5
MIC₉₀	1	1	1	4
Itraconazole
Range	<0.03 to >16^b	<0.03 to 0.5	<0.03 to 0.5	<0.03 to >16^b
Geometric mean	0.05	0.09	0.05	0.05
MIC₅₀	0.03	0.03	0.03	0.03
MIC₉₀	0.06	0.12	0.03	0.03
Amphotericin B
Range	0.007-0.5	0.007-0.25	0.007-0.25	0.007-0.5
Geometric mean	0.04	0.05	0.03	0.04
MIC₅₀	0.03	0.03	0.03	0.06
MIC₉₀	0.12	0.12	0.25	0.12

(MIC values are expressed in μg/ml)
^a Resistant (two C. tropicalis) and trailing effect (nine C. albicans, four C. tropicalis, and three C. parapsilosis)
^b Resistant (three C. tropicalis, one C. albicans), susceptibility dependence-dose (three C. albicans, two C. tropicalis and one C. parapsilosis) and trailing effect (six C. albicans, four C. tropicalis and one C. parapsilosis).

ISSN: 1476-0711