Skip to main content

Table 4 Fungicidal efficacy of benzaldehyde formulations (μg/ml) against individual strains of filamentous fungi examined1.

From: Antifungal activity of redox-active benzaldehydes that target cellular antioxidation

  

Compounds alone

  
  

Cinnamaldehyde

o -Vanillin

2-Hydroxy-5-methoxybenzaldehyde

2,3-D

Thymol

Formulation (combined)

Fungicidality MFC FORMULATION /MIC FORMULATION

A. fumigatus

AF293

MIC

(FEMIC)

MFC

(FEMFC)

32-64

(8 H)

64-128

(4 H)

32-64

(8 H)

> 128

(8 H)

32-64

(8 H)

> 128

(8 H)

8-16

(2 L)

> 128

(8 H)

> 128 2

(32 H)

N/D 3

(8 H)

4-8

16-32

4 (Fungicidal)4

A. terreus

UAB673

MIC

(FEMIC)

MFC

(FEMFC)

32-64

(8 H)

64-128

(4 H)

32-64

(8 H)

> 128

(8 H)

32-64

(8 H)

> 128

(8 H)

8-16

(2 L)

> 128

(8 H)

> 128

(32 H)

N/D

(8 H)

4-8

16-32

4 (Fungicidal)

A. terreus

UAB680

MIC

(FEMIC)

MFC

(FEMFC)

32-64

(4 H)

64-128

(4 H)

32-64

(4 H)

> 128

(8 H)

32-64

(4 H)

> 128

(8 H)

16-32

(2 L)

> 128

(8 H)

> 128

(16 H)

N/D

(8 H)

8-16

16-32

2 (Fungicidal)

A. terreus

UAB698

MIC

(FEMIC)

MFC

(FEMFC)

32-64

(4 H)

64-128

(4 H)

32-64

(4 H)

> 128

(8 H)

32-64

(4 H)

> 128

(8 H)

32-64

(4 H)

> 128

(8 H)

> 128

(16 H)

N/D

(8 H)

8-16

16-32

2 (Fungicidal)

A. flavus

NRRL3357

MIC

(FEMIC)

MFC

(FEMFC)

32-64

(4 H)

64-128

(4 H)

32-64

(4 H)

> 128

(8 H)

32-64

(4 H)

> 128

(8 H)

64-128

(8 H)

> 128

(8 H)

> 128

(16 H)

N/D

(8 H)

8-16

16-32

2 (Fungicidal)

P. expansum

NRRL974

MIC

(FEMIC)

MFC

(FEMFC)

32-64

(4 H)

32-64

(2 L)

32-64

(4 H)

> 128

(8 H)

32-64

(4 H)

> 128

(8 H)

32-64

(4 H)

> 128

(8 H)

> 128

(16 H)

N/D

(8 H)

8-16

16-32

2 (Fungicidal)

  1. 1 Efficacy of combined compounds compared to each compound alone is expressed as Formulation Efficacy (FEMIC or FEMFC; See Methods). FEMIC, FE for MIC values; FEMFC, FE for MFC values; H (high) if FE ≥ 4, L (low) if 1 < FE < 4; See Methods for calculations. For calculation purposes, higher concentration (μg/ml) of each concentration range was used for FE determination (e.g., 64 from 32 - 64 μg/ml).
  2. 2Assays were conducted up to a highest concentration of 128 μg/ml. For calculation purposes, 256 μg/ml (doubling of 128 μg/ml) was used.
  3. 3ND: Not determined since fungal growth occurred at the highest concentration (128 μg/ml). For calculation purposes, 256 μg/ml was used.
  4. 4Fungicidal or fungistatic effect was determined based on MFCFORMULATION/MICFORMULATION ratio (Fungicidal if ≤ 4, fungistatic if > 4; See Methods for calculations). For calculation purposes, higher concentration (μg/ml) of each MIC or MFC range was used.
Back to article page

Annals of Clinical Microbiology and Antimicrobials

ISSN: 1476-0711

Contact us