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Table 1 PCR-results with a total of 380 tissue samples obtained from non-infected (control) and N. caninum-infected calves without and with ponazuril therapy (1T = medication for one day; 6T = medication for 6 consecutive days). Bold numbers indicate the number of positive samples per total number of samples analyzed; – means that no sample was PCR-positive. Infected animals without therapy were euthanized on day 45 p.i. (nos. 1–3) and 90 p.i. (nos. 4–6)

From: An explorative study to assess the efficacy of Toltrazuril-sulfone (Ponazuril) in calves experimentally infected with Neospora caninum

  without infection infection, without therapy infection, with therapy
() = number of calves tested without therapy (2) with therapy_6T (2) no.1 (1) no.2 (1) no.3 (1) no.4 (1) no.5 (1) no.6 (1) with therapy_1T (5) with therapy_6T (4)
brain - / 20 - / 20 - / 10 2 / 10 - / 10 - / 10 1 / 10 - / 10 - /50 - /40
heart - / 6 - / 6 - / 3 - / 3 1 / 3 - / 3 - / 3 - / 3 - /15 - /12
muscles* - / 6 - / 6 - / 3 1 / 3 - / 3 - / 3 1 / 3 - / 3 - /15 - /12
liver - / 8 - / 8 - / 4 - / 4 - / 4 - / 4 - / 4 - / 4 - /20 - /16
  1. *muscles: per animal, one sample from the M. masseter, one from the diaphragma and one from the tongue, respectively.