Table 4 Genotypic characterization of linezolid resistance mechanism(s) in LR-MRSA isolates (n = 8) as revealed by numerous point mutations in the target location
Isolate Code | Linezolid resistance gene(s) | Linezolid (MICs; mg/L) |
|---|---|---|
9A | cfr(B), vanA, mecA, icaA, domain V region of 23S rRNA mutations (A2338T and C2610G) | 128 |
57A | vanA, mecA, icaA, L3 (rplC gene) mutations (Ser124Leu, Ile215Asn), and domain V region of 23S rRNA mutations (A2338T, and C2610G) | 32 |
90A | cfr(B), vanA, L3 (rplC gene) mutations (Gly75Thr, Thr179Ala, Ile215Asn), and domain V region of 23S rRNA mutations (A2338T, C2610G, G2482T, C2493A, A2498C, T2504C, G2528C, T2531C, C2534A, C2548G, T2555C, G2576T, G2603T, G2604T, T2607C) | 128 |
95A | vanA, mecA, icaA, L3 (rplC gene) mutations, (Ile215Asn), and domain V region of 23S rRNA mutations (C2610G, T2504C, G2528C, G2589T) | 8 |
112A | vanA, mecA, icaA, L4 (rplD gene) mutations (Leu2Tyr, Phe3Ser, Glu4Lys), and domain V region of 23S rRNA mutations (A2338T) | 64 |
117A | cfr(B), vanA, mecA, icaA, and L4 (rplD gene) mutations (Pro29Gln, Asn30Ile, Leu34Tyr) | 128 |
126A | vanA, mecA, icaA, and L4 (rplD gene) mutations (Glu28Ser) | 8 |
137A | vanA, L4 (rplD gene) mutations (Pro29Gln, Ser32Ala, Leu34Tyr), and domain V region of 23S rRNA mutations (A2338T, C2610G) | 16 |