Table 2 Fosfomycin general pharmacokinetics

Fosfomycin [g/24 h]

20 ± 6

Fosfomycin therapy [d]

13 ± 9

Fosfomycin CL [L/h]

4.2 ± 2.2

Fosfomycin serum level [mg/L] first measurement

209 [163–438]

Fosfomycin CSF level [mg/L] first measurement

104 [65–269]

Fosfomycin serum level [mg/L]—all samples

200 [159–289]

Fosfomycin CSF level [mg/L]—all samples

99 [66–144]

Fosfomycin penetration rate [%]

46 [36–59]

Fosfomycin AUC in serum [mg*h/L]

4800 [3816–7152]

Fosfomycin AUC in CSF [mg*h/L]

2381 [1586–3456]

AUC/MIC (32 mg/L) ratio in serum

150 [119–224]

AUC/MIC (32 mg/L) ratio in CSF

74 [50–108]